UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response

Despite the pivotal role of MYC in tumorigenesis, the mechanisms by which it promotes cancer aggressiveness remain incompletely understood. Here we show that MYC transcriptionally upregulates the ubiquitin fusion degradation 1 (UFD1) gene in T-cell acute lymphoblastic leukemia (T-ALL). Allelic loss...

Descripción completa

Detalles Bibliográficos
Autores principales: Huiting, LN, Samaha, Y, Zhang, GL, Roderick, JE, Li, B, Anderson, NM, Wang, YW, Wang, L, Laroche, FJF, Choi, JW, Liu, CT, Kelliher, MA, Feng, H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202254/
https://www.ncbi.nlm.nih.gov/pubmed/29743725
http://dx.doi.org/10.1038/s41375-018-0141-x

Ejemplares similares

Ejemplares similares