A screen of Crohn’s disease-associated microbial metabolites identifies ascorbate as a novel metabolic inhibitor of activated human T cells

Microbial metabolites are an emerging class of mediators influencing CD4+ T cell function. To advance the understanding of direct causal microbial factors contributing to Crohn’s disease, we screened 139 predicted Crohn’s disease-associated microbial metabolites for their bioactivity on human CD4+ T...

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Detalles Bibliográficos
Autores principales: Chang, Yu-Ling, Rossetti, Maura, Vlamakis, Hera, Casero, David, Sunga, Gemalene, Harre, Nicholas, Miller, Shelley, Humphries, Romney, Stappenbeck, Thaddeus, Simpson, Kenneth W., Sartor, R. Balfour, Wu, Gary, Lewis, James, Bushman, Frederic, McGovern, Dermot P.B., Salzman, Nita, Borneman, James, Xavier, Ramnik, Huttenhower, Curtis, Braun, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202286/
https://www.ncbi.nlm.nih.gov/pubmed/29695840
http://dx.doi.org/10.1038/s41385-018-0022-7

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