Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis

Antibiotic-resistant bacterial pathogens pose an urgent healthcare threat, prompting a demand for new medicines. We report the mode of action of the natural ansamycin antibiotic kanglemycin A (KglA). KglA binds bacterial RNA polymerase at the rifampicin-binding pocket but maintains potency against R...

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Detalles Bibliográficos
Autores principales: Mosaei, Hamed, Molodtsov, Vadim, Kepplinger, Bernhard, Harbottle, John, Moon, Christopher William, Jeeves, Rose Elizabeth, Ceccaroni, Lucia, Shin, Yeonoh, Morton-Laing, Stephanie, Marrs, Emma Claire Louise, Wills, Corinne, Clegg, William, Yuzenkova, Yulia, Perry, John David, Bacon, Joanna, Errington, Jeff, Allenby, Nicholas Edward Ellis, Hall, Michael John, Murakami, Katsuhiko S., Zenkin, Nikolay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202310/
https://www.ncbi.nlm.nih.gov/pubmed/30244835
http://dx.doi.org/10.1016/j.molcel.2018.08.028

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