Repression of Mcl-1 expression by the CDC7/CDK9 inhibitor PHA-767491 overcomes bone marrow stroma-mediated drug resistance in AML

Acute myeloid leukaemia (AML) is an aggressive cancer with 50–75% of patients relapsing even after successful chemotherapy. The role of the bone marrow microenvironment (BMM) in protecting AML cells from chemotherapeutics and causing consequent relapse is increasingly recognised. However the role th...

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Detalles Bibliográficos
Autores principales: O’ Reilly, Eimear, Dhami, Sukhraj Pal S., Baev, Denis V., Ortutay, Csaba, Halpin-McCormick, Anna, Morrell, Ruth, Santocanale, Corrado, Samali, Afshin, Quinn, John, O’Dwyer, Michael E, Szegezdi, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202320/
https://www.ncbi.nlm.nih.gov/pubmed/30361682
http://dx.doi.org/10.1038/s41598-018-33982-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202320/
https://www.ncbi.nlm.nih.gov/pubmed/30361682
http://dx.doi.org/10.1038/s41598-018-33982-y

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