PHLPP2 stabilization by p27 mediates its inhibition of bladder cancer invasion by promoting autophagic degradation of MMP2 protein

Pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2) is a tumor suppressor that catalyzes the de-phosphorylation of the AGC kinases, while p27 acts as a tumor suppressor that regulates cell cycle, apoptosis, and cell motility. Our previous studies have identified that PHLPP2...

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Detalles Bibliográficos
Autores principales: Peng, Minggang, Wang, Jingjing, Zhang, Dongyun, Jin, Honglei, Li, Jingxia, Wu, Xue-Ru, Huang, Chuanshu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202328/
https://www.ncbi.nlm.nih.gov/pubmed/29930380
http://dx.doi.org/10.1038/s41388-018-0374-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202328/
https://www.ncbi.nlm.nih.gov/pubmed/29930380
http://dx.doi.org/10.1038/s41388-018-0374-1

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