The dimer-dependent catalytic activity of RAF family kinases is revealed through characterizing their oncogenic mutants

Although extensively studied for three decades, the molecular mechanisms that regulate the RAF/MEK/ERK kinase cascade remain ambiguous. Recent studies identified the dimerization of RAF as a key event in the activation of this cascade. Here, we show that in-frame deletions in the β3-αC loop activate...

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Detalles Bibliográficos
Autores principales: Yuan, Jimin, Ng, Wan Hwa, Lam, Paula Y. P., Wang, Yu, Xia, Hongping, Yap, Jiajun, Guan, Shou Ping, Lee, Ann S. G., Wang, Mei, Baccarini, Manuela, Hu, Jiancheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202329/
https://www.ncbi.nlm.nih.gov/pubmed/29930381
http://dx.doi.org/10.1038/s41388-018-0365-2

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