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Microperimetry and multimodal imaging in polypoidal choroidal vasculopathy

Polypoidal choroidal vasculopathy (PCV) is a degenerative macular disease. The study determined the topographical concordance in the areal extent of PCV, defined by indocyanine green angiography (ICGA), and the corresponding outcomes from spectral-domain optical coherence tomography (SD-OCT) and mic...

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Autores principales: Acton, Jennifer H., Ogino, Ken, Akagi, Yumiko, Wild, John M., Yoshimura, Nagahisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202363/
https://www.ncbi.nlm.nih.gov/pubmed/30361520
http://dx.doi.org/10.1038/s41598-018-33781-5
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author Acton, Jennifer H.
Ogino, Ken
Akagi, Yumiko
Wild, John M.
Yoshimura, Nagahisa
author_facet Acton, Jennifer H.
Ogino, Ken
Akagi, Yumiko
Wild, John M.
Yoshimura, Nagahisa
author_sort Acton, Jennifer H.
collection PubMed
description Polypoidal choroidal vasculopathy (PCV) is a degenerative macular disease. The study determined the topographical concordance in the areal extent of PCV, defined by indocyanine green angiography (ICGA), and the corresponding outcomes from spectral-domain optical coherence tomography (SD-OCT) and microperimetry, in 25 individuals (25 eyes) who had undergone 3 months of anti-vascular endothelial growth factor treatment. The differential light sensitivity within 10° eccentricity was evaluated by Pattern Deviation probability analysis. The concordances and proportional areal extents of the abnormality for ICGA, SD-OCT and microperimetry were compared. The concordance in the areal extent between all three modalities was 59%. The median concordance between ICGA and microperimetry was 60%; between ICGA and SD-OCT, 70%; and between SD-OCT and microperimetry, 72%. SD-OCT and microperimetry each identified a greater areal extent (>20%) compared to ICGA in 13 and 19 eyes, respectively. A greater areal extent (>20%) was present in 9 eyes for microperimetry compared to SD-OCT and in 5 eyes for SD-OCT compared to microperimetry. SD-OCT and microperimetry each identified a greater area of abnormality than ICGA which supports the clinical utility of SD-OCT. Strong concordance was present between SD-OCT and microperimetry; however, microperimetry identified additional areas of functional abnormality.
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spelling pubmed-62023632018-10-29 Microperimetry and multimodal imaging in polypoidal choroidal vasculopathy Acton, Jennifer H. Ogino, Ken Akagi, Yumiko Wild, John M. Yoshimura, Nagahisa Sci Rep Article Polypoidal choroidal vasculopathy (PCV) is a degenerative macular disease. The study determined the topographical concordance in the areal extent of PCV, defined by indocyanine green angiography (ICGA), and the corresponding outcomes from spectral-domain optical coherence tomography (SD-OCT) and microperimetry, in 25 individuals (25 eyes) who had undergone 3 months of anti-vascular endothelial growth factor treatment. The differential light sensitivity within 10° eccentricity was evaluated by Pattern Deviation probability analysis. The concordances and proportional areal extents of the abnormality for ICGA, SD-OCT and microperimetry were compared. The concordance in the areal extent between all three modalities was 59%. The median concordance between ICGA and microperimetry was 60%; between ICGA and SD-OCT, 70%; and between SD-OCT and microperimetry, 72%. SD-OCT and microperimetry each identified a greater areal extent (>20%) compared to ICGA in 13 and 19 eyes, respectively. A greater areal extent (>20%) was present in 9 eyes for microperimetry compared to SD-OCT and in 5 eyes for SD-OCT compared to microperimetry. SD-OCT and microperimetry each identified a greater area of abnormality than ICGA which supports the clinical utility of SD-OCT. Strong concordance was present between SD-OCT and microperimetry; however, microperimetry identified additional areas of functional abnormality. Nature Publishing Group UK 2018-10-25 /pmc/articles/PMC6202363/ /pubmed/30361520 http://dx.doi.org/10.1038/s41598-018-33781-5 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Acton, Jennifer H.
Ogino, Ken
Akagi, Yumiko
Wild, John M.
Yoshimura, Nagahisa
Microperimetry and multimodal imaging in polypoidal choroidal vasculopathy
title Microperimetry and multimodal imaging in polypoidal choroidal vasculopathy
title_full Microperimetry and multimodal imaging in polypoidal choroidal vasculopathy
title_fullStr Microperimetry and multimodal imaging in polypoidal choroidal vasculopathy
title_full_unstemmed Microperimetry and multimodal imaging in polypoidal choroidal vasculopathy
title_short Microperimetry and multimodal imaging in polypoidal choroidal vasculopathy
title_sort microperimetry and multimodal imaging in polypoidal choroidal vasculopathy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202363/
https://www.ncbi.nlm.nih.gov/pubmed/30361520
http://dx.doi.org/10.1038/s41598-018-33781-5
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