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The common origin of symmetry and structure in genetic sequences
Biologists have long sought a way to explain how statistical properties of genetic sequences emerged and are maintained through evolution. On the one hand, non-random structures at different scales indicate a complex genome organisation. On the other hand, single-strand symmetry has been scrutinised...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202410/ https://www.ncbi.nlm.nih.gov/pubmed/30361485 http://dx.doi.org/10.1038/s41598-018-34136-w |
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author | Cristadoro, Giampaolo Degli Esposti, Mirko Altmann, Eduardo G. |
author_facet | Cristadoro, Giampaolo Degli Esposti, Mirko Altmann, Eduardo G. |
author_sort | Cristadoro, Giampaolo |
collection | PubMed |
description | Biologists have long sought a way to explain how statistical properties of genetic sequences emerged and are maintained through evolution. On the one hand, non-random structures at different scales indicate a complex genome organisation. On the other hand, single-strand symmetry has been scrutinised using neutral models in which correlations are not considered or irrelevant, contrary to empirical evidence. Different studies investigated these two statistical features separately, reaching minimal consensus despite sustained efforts. Here we unravel previously unknown symmetries in genetic sequences, which are organized hierarchically through scales in which non-random structures are known to be present. These observations are confirmed through the statistical analysis of the human genome and explained through a simple domain model. These results suggest that domain models which account for the cumulative action of mobile elements can explain simultaneously non-random structures and symmetries in genetic sequences. |
format | Online Article Text |
id | pubmed-6202410 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-62024102018-10-29 The common origin of symmetry and structure in genetic sequences Cristadoro, Giampaolo Degli Esposti, Mirko Altmann, Eduardo G. Sci Rep Article Biologists have long sought a way to explain how statistical properties of genetic sequences emerged and are maintained through evolution. On the one hand, non-random structures at different scales indicate a complex genome organisation. On the other hand, single-strand symmetry has been scrutinised using neutral models in which correlations are not considered or irrelevant, contrary to empirical evidence. Different studies investigated these two statistical features separately, reaching minimal consensus despite sustained efforts. Here we unravel previously unknown symmetries in genetic sequences, which are organized hierarchically through scales in which non-random structures are known to be present. These observations are confirmed through the statistical analysis of the human genome and explained through a simple domain model. These results suggest that domain models which account for the cumulative action of mobile elements can explain simultaneously non-random structures and symmetries in genetic sequences. Nature Publishing Group UK 2018-10-25 /pmc/articles/PMC6202410/ /pubmed/30361485 http://dx.doi.org/10.1038/s41598-018-34136-w Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Cristadoro, Giampaolo Degli Esposti, Mirko Altmann, Eduardo G. The common origin of symmetry and structure in genetic sequences |
title | The common origin of symmetry and structure in genetic sequences |
title_full | The common origin of symmetry and structure in genetic sequences |
title_fullStr | The common origin of symmetry and structure in genetic sequences |
title_full_unstemmed | The common origin of symmetry and structure in genetic sequences |
title_short | The common origin of symmetry and structure in genetic sequences |
title_sort | common origin of symmetry and structure in genetic sequences |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202410/ https://www.ncbi.nlm.nih.gov/pubmed/30361485 http://dx.doi.org/10.1038/s41598-018-34136-w |
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