USP7 deubiquitinates and stabilizes NOTCH1 in T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive leukemia that is primarily caused by aberrant activation of the NOTCH1 signaling pathway. Recent studies have revealed that posttranslational modifications, such as ubiquitination, regulate NOTCH1 stability, activity, and localizatio...

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Detalles Bibliográficos
Autores principales: Shan, Huizhuang, Li, Xiangyun, Xiao, Xinhua, Dai, Yuting, Huang, Jinyan, Song, Junjun, Liu, Meng, Yang, Li, Lei, Hu, Tong, Yin, Zhou, Li, Xu, Hanzhang, Wu, Yingli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202415/
https://www.ncbi.nlm.nih.gov/pubmed/30370059
http://dx.doi.org/10.1038/s41392-018-0028-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202415/
https://www.ncbi.nlm.nih.gov/pubmed/30370059
http://dx.doi.org/10.1038/s41392-018-0028-3

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