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Semimechanistic Population Pharmacokinetic Model to Predict the Drug–Drug Interaction Between S‐ketamine and Ticlopidine in Healthy Human Volunteers

Low‐dose oral S‐ketamine is increasingly used in chronic pain therapy, but extensive cytochrome P450 (CYP) mediated metabolism makes it prone to pharmacokinetic drug‐drug interactions (DDIs). In our study, concentration‐time data from five studies were used to develop a semimechanistic model that de...

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Detalles Bibliográficos
Autores principales:	Ashraf, Muhammad W., Peltoniemi, Marko A., Olkkola, Klaus T., Neuvonen, Pertti J., Saari, Teijo I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202471/ https://www.ncbi.nlm.nih.gov/pubmed/30091858 http://dx.doi.org/10.1002/psp4.12346

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