Perspective on the State of Pharmacometrics and Systems Pharmacology Integration

Reliance on modeling and simulation in drug discovery and development has dramatically increased over the past decade. Two disciplines at the forefront of this activity, pharmacometrics and systems pharmacology (SP), emerged independently from different fields; consequently, a perception exists that...

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Autores principales: Trame, Mirjam N., Riggs, Matthew, Biliouris, Konstantinos, Marathe, Dhananjay, Mettetal, Jerome, Post, Teun M., Rizk, Matthew L., Visser, Sandra A. G., Musante, Cynthia J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202472/
https://www.ncbi.nlm.nih.gov/pubmed/29761892
http://dx.doi.org/10.1002/psp4.12313
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author Trame, Mirjam N.
Riggs, Matthew
Biliouris, Konstantinos
Marathe, Dhananjay
Mettetal, Jerome
Post, Teun M.
Rizk, Matthew L.
Visser, Sandra A. G.
Musante, Cynthia J.
author_facet Trame, Mirjam N.
Riggs, Matthew
Biliouris, Konstantinos
Marathe, Dhananjay
Mettetal, Jerome
Post, Teun M.
Rizk, Matthew L.
Visser, Sandra A. G.
Musante, Cynthia J.
author_sort Trame, Mirjam N.
collection PubMed
description Reliance on modeling and simulation in drug discovery and development has dramatically increased over the past decade. Two disciplines at the forefront of this activity, pharmacometrics and systems pharmacology (SP), emerged independently from different fields; consequently, a perception exists that only few examples integrate these approaches. Herein, we review the state of pharmacometrics and SP integration and describe benefits of combining these approaches in a model‐informed drug discovery and development framework.
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spelling pubmed-62024722018-10-31 Perspective on the State of Pharmacometrics and Systems Pharmacology Integration Trame, Mirjam N. Riggs, Matthew Biliouris, Konstantinos Marathe, Dhananjay Mettetal, Jerome Post, Teun M. Rizk, Matthew L. Visser, Sandra A. G. Musante, Cynthia J. CPT Pharmacometrics Syst Pharmacol Perspective Reliance on modeling and simulation in drug discovery and development has dramatically increased over the past decade. Two disciplines at the forefront of this activity, pharmacometrics and systems pharmacology (SP), emerged independently from different fields; consequently, a perception exists that only few examples integrate these approaches. Herein, we review the state of pharmacometrics and SP integration and describe benefits of combining these approaches in a model‐informed drug discovery and development framework. John Wiley and Sons Inc. 2018-08-21 2018-10 /pmc/articles/PMC6202472/ /pubmed/29761892 http://dx.doi.org/10.1002/psp4.12313 Text en © 2018 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Perspective
Trame, Mirjam N.
Riggs, Matthew
Biliouris, Konstantinos
Marathe, Dhananjay
Mettetal, Jerome
Post, Teun M.
Rizk, Matthew L.
Visser, Sandra A. G.
Musante, Cynthia J.
Perspective on the State of Pharmacometrics and Systems Pharmacology Integration
title Perspective on the State of Pharmacometrics and Systems Pharmacology Integration
title_full Perspective on the State of Pharmacometrics and Systems Pharmacology Integration
title_fullStr Perspective on the State of Pharmacometrics and Systems Pharmacology Integration
title_full_unstemmed Perspective on the State of Pharmacometrics and Systems Pharmacology Integration
title_short Perspective on the State of Pharmacometrics and Systems Pharmacology Integration
title_sort perspective on the state of pharmacometrics and systems pharmacology integration
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202472/
https://www.ncbi.nlm.nih.gov/pubmed/29761892
http://dx.doi.org/10.1002/psp4.12313
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