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Predicting the Onset of Nonlinear Pharmacokinetics
When analyzing the pharmacokinetics (PK) of drugs, one is often faced with concentration C vs. time curves, which display a sharp transition at a critical concentration C (crit). For C > C (crit), the curve displays linear clearance and for C < C (crit) clearance increases in a nonlinear manne...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202475/ https://www.ncbi.nlm.nih.gov/pubmed/30196577 http://dx.doi.org/10.1002/psp4.12316 |