Wentilactone A induces cell apoptosis by targeting AKR1C1 gene via the IGF-1R/IRS1/PI3K/AKT/Nrf2/FLIP/Caspase-3 signaling pathway in small cell lung cancer

Wentilactone A (WA), a marine-derived compound, inhibits proliferation of NCI-H446, as demonstrated by previous research; however, the anti-SCLC mechanism underlying WA was not fully investigated. The present study aimed to investigate the anti-SCLC mechanism underlying WA in vitro and in vivo. Cell...

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Detalles Bibliográficos
Autores principales: Jiang, Wenli, Meng, Linghong, Xu, Guangming, Lv, Cuiting, Wang, Hongliang, Tian, He, Chen, Ruohua, Jiao, Binghua, Wang, Bingui, Huang, Caiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202482/
https://www.ncbi.nlm.nih.gov/pubmed/30405782
http://dx.doi.org/10.3892/ol.2018.9486

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