Analyses and treatment of simultaneous bi-lineage malignancies of myeloid leukemia and lymphoma: Two case reports and a literature review

The present study reports two cases of concurrently diagnosed T-lymphoblastic lymphoma (T-LBL) and chronic myeloid leukemia (CML). The literature review revealed that myeloid leukemia may appear secondary to Hodgkin lymphoma or non-Hodgkin lymphoma. However, simultaneous bi-lineage hematologic malig...

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Autores principales: Fu, Xiaorui, Shang, Yufeng, Zhang, Lei, Li, Ling, Li, Xin, Wang, Xinhua, Sun, Zhenchang, Zhang, Mingzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202486/
https://www.ncbi.nlm.nih.gov/pubmed/30405801
http://dx.doi.org/10.3892/ol.2018.9447
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author Fu, Xiaorui
Shang, Yufeng
Zhang, Lei
Li, Ling
Li, Xin
Wang, Xinhua
Sun, Zhenchang
Zhang, Mingzhi
author_facet Fu, Xiaorui
Shang, Yufeng
Zhang, Lei
Li, Ling
Li, Xin
Wang, Xinhua
Sun, Zhenchang
Zhang, Mingzhi
author_sort Fu, Xiaorui
collection PubMed
description The present study reports two cases of concurrently diagnosed T-lymphoblastic lymphoma (T-LBL) and chronic myeloid leukemia (CML). The literature review revealed that myeloid leukemia may appear secondary to Hodgkin lymphoma or non-Hodgkin lymphoma. However, simultaneous bi-lineage hematologic malignancies are rarely seen and the prognosis is worse than single lineage lymphoma or myeloid leukemia. There were no standard therapies. All simultaneous bi-lineage malignancies of myeloid leukemia and lymphoma reported in Pubmed were combined with the present two cases, to analyses its pathogenesis, features and treatment. It was concluded that the prognosis of bi-lineage hematologic malignancies was poor, however allogeneic hematopoietic stem cell transplantation could improve survival (P=0.033).
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spelling pubmed-62024862018-11-07 Analyses and treatment of simultaneous bi-lineage malignancies of myeloid leukemia and lymphoma: Two case reports and a literature review Fu, Xiaorui Shang, Yufeng Zhang, Lei Li, Ling Li, Xin Wang, Xinhua Sun, Zhenchang Zhang, Mingzhi Oncol Lett Articles The present study reports two cases of concurrently diagnosed T-lymphoblastic lymphoma (T-LBL) and chronic myeloid leukemia (CML). The literature review revealed that myeloid leukemia may appear secondary to Hodgkin lymphoma or non-Hodgkin lymphoma. However, simultaneous bi-lineage hematologic malignancies are rarely seen and the prognosis is worse than single lineage lymphoma or myeloid leukemia. There were no standard therapies. All simultaneous bi-lineage malignancies of myeloid leukemia and lymphoma reported in Pubmed were combined with the present two cases, to analyses its pathogenesis, features and treatment. It was concluded that the prognosis of bi-lineage hematologic malignancies was poor, however allogeneic hematopoietic stem cell transplantation could improve survival (P=0.033). D.A. Spandidos 2018-11 2018-09-18 /pmc/articles/PMC6202486/ /pubmed/30405801 http://dx.doi.org/10.3892/ol.2018.9447 Text en Copyright: © Fu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Fu, Xiaorui
Shang, Yufeng
Zhang, Lei
Li, Ling
Li, Xin
Wang, Xinhua
Sun, Zhenchang
Zhang, Mingzhi
Analyses and treatment of simultaneous bi-lineage malignancies of myeloid leukemia and lymphoma: Two case reports and a literature review
title Analyses and treatment of simultaneous bi-lineage malignancies of myeloid leukemia and lymphoma: Two case reports and a literature review
title_full Analyses and treatment of simultaneous bi-lineage malignancies of myeloid leukemia and lymphoma: Two case reports and a literature review
title_fullStr Analyses and treatment of simultaneous bi-lineage malignancies of myeloid leukemia and lymphoma: Two case reports and a literature review
title_full_unstemmed Analyses and treatment of simultaneous bi-lineage malignancies of myeloid leukemia and lymphoma: Two case reports and a literature review
title_short Analyses and treatment of simultaneous bi-lineage malignancies of myeloid leukemia and lymphoma: Two case reports and a literature review
title_sort analyses and treatment of simultaneous bi-lineage malignancies of myeloid leukemia and lymphoma: two case reports and a literature review
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202486/
https://www.ncbi.nlm.nih.gov/pubmed/30405801
http://dx.doi.org/10.3892/ol.2018.9447
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