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Stem cell therapy for treating osteonecrosis of the femoral head: From clinical applications to related basic research

Osteonecrosis of the femoral head (ONFH) is a refractory disease that is associated with collapse of the femoral head, with a risk of hip arthroplasty in younger populations. Thus, there has been an increased focus on early interventions for ONFH that aim to preserve the native articulation. Stem ce...

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Autores principales: Li, Rui, Lin, Qiu-Xia, Liang, Xue-Zhen, Liu, Guang-Bo, Tang, He, Wang, Yu, Lu, Shi-Bi, Peng, Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202807/
https://www.ncbi.nlm.nih.gov/pubmed/30359305
http://dx.doi.org/10.1186/s13287-018-1018-7
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author Li, Rui
Lin, Qiu-Xia
Liang, Xue-Zhen
Liu, Guang-Bo
Tang, He
Wang, Yu
Lu, Shi-Bi
Peng, Jiang
author_facet Li, Rui
Lin, Qiu-Xia
Liang, Xue-Zhen
Liu, Guang-Bo
Tang, He
Wang, Yu
Lu, Shi-Bi
Peng, Jiang
author_sort Li, Rui
collection PubMed
description Osteonecrosis of the femoral head (ONFH) is a refractory disease that is associated with collapse of the femoral head, with a risk of hip arthroplasty in younger populations. Thus, there has been an increased focus on early interventions for ONFH that aim to preserve the native articulation. Stem cell therapy is a promising treatment, and an increasing number of recent studies have focused on this topic. Many clinical studies have reported positive outcomes of stem cell therapy for the treatment of ONFH. To improve the therapeutic effects of this approach, many related basic research studies have also been performed. However, some issues must be further explored, such as the appropriate patient selection procedure, the optimal stem cell selection protocol, the ideal injection number, and the safety of stem cell therapy. The purpose of this review is to summarize the available clinical studies and basic research related to stem cell therapy for ONFH.
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spelling pubmed-62028072018-11-01 Stem cell therapy for treating osteonecrosis of the femoral head: From clinical applications to related basic research Li, Rui Lin, Qiu-Xia Liang, Xue-Zhen Liu, Guang-Bo Tang, He Wang, Yu Lu, Shi-Bi Peng, Jiang Stem Cell Res Ther Review Osteonecrosis of the femoral head (ONFH) is a refractory disease that is associated with collapse of the femoral head, with a risk of hip arthroplasty in younger populations. Thus, there has been an increased focus on early interventions for ONFH that aim to preserve the native articulation. Stem cell therapy is a promising treatment, and an increasing number of recent studies have focused on this topic. Many clinical studies have reported positive outcomes of stem cell therapy for the treatment of ONFH. To improve the therapeutic effects of this approach, many related basic research studies have also been performed. However, some issues must be further explored, such as the appropriate patient selection procedure, the optimal stem cell selection protocol, the ideal injection number, and the safety of stem cell therapy. The purpose of this review is to summarize the available clinical studies and basic research related to stem cell therapy for ONFH. BioMed Central 2018-10-25 /pmc/articles/PMC6202807/ /pubmed/30359305 http://dx.doi.org/10.1186/s13287-018-1018-7 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Li, Rui
Lin, Qiu-Xia
Liang, Xue-Zhen
Liu, Guang-Bo
Tang, He
Wang, Yu
Lu, Shi-Bi
Peng, Jiang
Stem cell therapy for treating osteonecrosis of the femoral head: From clinical applications to related basic research
title Stem cell therapy for treating osteonecrosis of the femoral head: From clinical applications to related basic research
title_full Stem cell therapy for treating osteonecrosis of the femoral head: From clinical applications to related basic research
title_fullStr Stem cell therapy for treating osteonecrosis of the femoral head: From clinical applications to related basic research
title_full_unstemmed Stem cell therapy for treating osteonecrosis of the femoral head: From clinical applications to related basic research
title_short Stem cell therapy for treating osteonecrosis of the femoral head: From clinical applications to related basic research
title_sort stem cell therapy for treating osteonecrosis of the femoral head: from clinical applications to related basic research
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202807/
https://www.ncbi.nlm.nih.gov/pubmed/30359305
http://dx.doi.org/10.1186/s13287-018-1018-7
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