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Time to death predictors of HIV/AIDS infected patients on antiretroviral therapy in Ethiopia

OBJECTIVE: The purpose of this study was to identify the major risk factors, which contributed to shortened survival time to death of HIV patients on antiretroviral therapy. Six-hundred HIV patients were included from two hospitals and six health centers record from January 2003 to December 2017. Ka...

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Autor principal: Tadege, Melaku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202867/
https://www.ncbi.nlm.nih.gov/pubmed/30359289
http://dx.doi.org/10.1186/s13104-018-3863-y
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author Tadege, Melaku
author_facet Tadege, Melaku
author_sort Tadege, Melaku
collection PubMed
description OBJECTIVE: The purpose of this study was to identify the major risk factors, which contributed to shortened survival time to death of HIV patients on antiretroviral therapy. Six-hundred HIV patients were included from two hospitals and six health centers record from January 2003 to December 2017. Kaplan–Meier and Cox proportional hazard model were implemented. RESULTS: From the Kaplan–Meier, log-rank test result indicated that there was a significant difference between tuberculosis comorbidity (P = .000), occupation (P = .027), and WHO clinical stage (P = .012) on the survival experience of patients at 5% statistical significance level. From the Cox regression result, the risk of death for patients who lived with tuberculosis was about 2.872-fold times higher than those patients who were negative. Most of the HIV/AIDS patients on antiretroviral therapy were died in a short period due to tuberculosis comorbidity, began with lower amount of CD4, being underweight, merchant, and being on WHO clinical stage IV. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13104-018-3863-y) contains supplementary material, which is available to authorized users.
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spelling pubmed-62028672018-11-01 Time to death predictors of HIV/AIDS infected patients on antiretroviral therapy in Ethiopia Tadege, Melaku BMC Res Notes Research Note OBJECTIVE: The purpose of this study was to identify the major risk factors, which contributed to shortened survival time to death of HIV patients on antiretroviral therapy. Six-hundred HIV patients were included from two hospitals and six health centers record from January 2003 to December 2017. Kaplan–Meier and Cox proportional hazard model were implemented. RESULTS: From the Kaplan–Meier, log-rank test result indicated that there was a significant difference between tuberculosis comorbidity (P = .000), occupation (P = .027), and WHO clinical stage (P = .012) on the survival experience of patients at 5% statistical significance level. From the Cox regression result, the risk of death for patients who lived with tuberculosis was about 2.872-fold times higher than those patients who were negative. Most of the HIV/AIDS patients on antiretroviral therapy were died in a short period due to tuberculosis comorbidity, began with lower amount of CD4, being underweight, merchant, and being on WHO clinical stage IV. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13104-018-3863-y) contains supplementary material, which is available to authorized users. BioMed Central 2018-10-25 /pmc/articles/PMC6202867/ /pubmed/30359289 http://dx.doi.org/10.1186/s13104-018-3863-y Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Note
Tadege, Melaku
Time to death predictors of HIV/AIDS infected patients on antiretroviral therapy in Ethiopia
title Time to death predictors of HIV/AIDS infected patients on antiretroviral therapy in Ethiopia
title_full Time to death predictors of HIV/AIDS infected patients on antiretroviral therapy in Ethiopia
title_fullStr Time to death predictors of HIV/AIDS infected patients on antiretroviral therapy in Ethiopia
title_full_unstemmed Time to death predictors of HIV/AIDS infected patients on antiretroviral therapy in Ethiopia
title_short Time to death predictors of HIV/AIDS infected patients on antiretroviral therapy in Ethiopia
title_sort time to death predictors of hiv/aids infected patients on antiretroviral therapy in ethiopia
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202867/
https://www.ncbi.nlm.nih.gov/pubmed/30359289
http://dx.doi.org/10.1186/s13104-018-3863-y
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