Cargando…

PBF509, an Adenosine A(2A) Receptor Antagonist With Efficacy in Rodent Models of Movement Disorders

Adenosine A(2A) receptor (A(2A)R) antagonists have emerged as complementary non-dopaminergic drugs to alleviate Parkinson’s disease (PD) symptomatology. Here, we characterize a novel non-xhantine non-furan A(2A)R antagonist, PBF509, as a potential pro-dopaminergic drug for PD management. First, PBF5...

Descripción completa

Detalles Bibliográficos
Autores principales:	Núñez, Fabiana, Taura, Jaume, Camacho, Juan, López-Cano, Marc, Fernández-Dueñas, Víctor, Castro, Naomi, Castro, Julio, Ciruela, Francisco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202948/ https://www.ncbi.nlm.nih.gov/pubmed/30405415 http://dx.doi.org/10.3389/fphar.2018.01200

Ejemplares similares

Antiparkinsonian Efficacy of Guanosine in Rodent Models of Movement Disorder
por: Massari, Caio M., et al.
Publicado: (2017)

Striatal Dopamine D(2)-Muscarinic Acetylcholine M(1) Receptor–Receptor Interaction in a Model of Movement Disorders
por: Crans, René A. J., et al.
Publicado: (2020)

Corrigendum: Striatal dopamine D2-muscarinic acetylcholine M1 receptor-receptor interaction in a model of movement disorders
por: Crans, René A. J., et al.
Publicado: (2022)

Uncovering Caffeine’s Adenosine A(2A) Receptor Inverse Agonism in Experimental Parkinsonism
por: Fernández-Dueñas, Víctor, et al.
Publicado: (2014)

Untangling dopamine-adenosine receptor-receptor assembly in experimental parkinsonism in rats
por: Fernández-Dueñas, Víctor, et al.
Publicado: (2015)

Photomodulation of G Protein-Coupled Adenosine Receptors by a Novel Light-Switchable Ligand
por: Bahamonde, María Isabel, et al.
Publicado: (2014)

Optical Control of Adenosine-Mediated Pain Modulation
por: Hüll, Katharina, et al.
Publicado: (2021)

Exploring Drug-Receptor Interaction Kinetics: Lessons from a Sigma-1 Receptor Transmembrane Biosensor
por: Fernández-Dueñas, Víctor, et al.
Publicado: (2017)

Pridopidine Reverses Phencyclidine-Induced Memory Impairment
por: Sahlholm, Kristoffer, et al.
Publicado: (2018)

Essential Control of the Function of the Striatopallidal Neuron by Pre-coupled Complexes of Adenosine A(2A)-Dopamine D(2) Receptor Heterotetramers and Adenylyl Cyclase
por: Ferré, Sergi, et al.
Publicado: (2018)

Caffeine and Selective Adenosine Receptor Antagonists as New Therapeutic Tools for the Motivational Symptoms of Depression
por: López-Cruz, Laura, et al.
Publicado: (2018)

Adenosine A(2A)-dopamine D(2) receptor heteromers operate striatal function: impact on Parkinson's disease pharmacotherapeutics
por: Fernández-Dueñas, Víctor, et al.
Publicado: (2018)

Inhibition of A(2A) Adenosine Receptor Signaling in Cancer Cells Proliferation by the Novel Antagonist TP455
por: Gessi, Stefania, et al.
Publicado: (2017)

Sleep Disorders in Rodent Models of Parkinson’s Disease
por: Medeiros, Daniel de Castro, et al.
Publicado: (2019)

Orexin-1 and orexin-2 receptor antagonists reduce ethanol self-administration in high-drinking rodent models
por: Anderson, Rachel I., et al.
Publicado: (2014)

Adenosine A(1)-A(2A) Receptor Heteromer as a Possible Target for Early-Onset Parkinson's Disease
por: Fernández-Dueñas, Víctor, et al.
Publicado: (2017)

Adenosine in the Thymus
por: Köröskényi, Krisztina, et al.
Publicado: (2017)

PBF, a Proto-oncogene in Esophageal Carcinoma
por: Lian, Shi-hai, et al.
Publicado: (2019)

The mGlu(5) Receptor Protomer-Mediated Dopamine D(2) Receptor Trans-Inhibition Is Dependent on the Adenosine A(2A) Receptor Protomer: Implications for Parkinson’s Disease
por: Romero-Fernandez, Wilber, et al.
Publicado: (2022)

Potential Treat-to-Target Approach for Methamphetamine Use Disorder: A Pilot Study of Adenosine 2A Receptor Antagonist With Positron Emission Tomography
por: Okita, Kyoji, et al.
Publicado: (2022)

The adenosine A(2A) receptor antagonist KW6002 distinctly regulates retinal ganglion cell morphology during postnatal development and neonatal inflammation
por: Hu, Shisi, et al.
Publicado: (2022)

Inhibition of pre-ischeamic conditioning in the mouse caudate brain slice by NMDA- or adenosine A(1) receptor antagonists
por: Chauhan, Nikky K., et al.
Publicado: (2013)

Adenosine Kinase on Deoxyribonucleic Acid Methylation: Adenosine Receptor-Independent Pathway in Cancer Therapy
por: Luo, Hao-Yun, et al.
Publicado: (2022)

Special Issue: Adenosine Receptors
por: Ciruela, Francisco, et al.
Publicado: (2017)

The Parkinson’s disease-associated GPR37 receptor interacts with striatal adenosine A(2A) receptor controlling its cell surface expression and function in vivo
por: Morató, Xavier, et al.
Publicado: (2017)

Real-world patterns of opioid therapy initiation in Spain, 2012–2018: A population-based, retrospective cohort study with 957,080 patients and 1,509,488 initiations
por: Hurtado, Isabel, et al.
Publicado: (2022)

Who Is Who in Adenosine Transport
por: Pastor-Anglada, Marçal, et al.
Publicado: (2018)

Corrigendum: Adenosine kinase on deoxyribonucleic acid methylation: Adenosine receptor-independent pathway in cancer therapy
por: Luo, Hao-Yun, et al.
Publicado: (2023)

Exploring the Effect of Halogenation in a Series of Potent and Selective A(2B) Adenosine Receptor Antagonists
por: Prieto-Díaz, Rubén, et al.
Publicado: (2022)

The Guanine-Based Purinergic System: The Tale of An Orphan Neuromodulation
por: Di Liberto, Valentina, et al.
Publicado: (2016)

Molecular Evidence of Adenosine Deaminase Linking Adenosine A(2A) Receptor and CD26 Proteins
por: Moreno, Estefanía, et al.
Publicado: (2018)

The Role of Adenosine Receptors in Psychostimulant Addiction
por: Ballesteros-Yáñez, Inmaculada, et al.
Publicado: (2018)

ATP and Adenosine in the Retina and Retinal Diseases
por: Ye, Shan-Shan, et al.
Publicado: (2021)

Metabolic Aspects of Adenosine Functions in the Brain
por: Garcia-Gil, Mercedes, et al.
Publicado: (2021)

SAT-509 Sudden Onset of Malabsorption
por: Mroueh, Gabriela, et al.
Publicado: (2020)

PBF-EB of Fe-Cr-V Alloy for Wear Applications
por: Franke-Jurisch, Marie, et al.
Publicado: (2022)

Measuring the Cooling Behavior of Melt Pools in L-PBF by Pyrometry
por: Pfaff, Aron, et al.
Publicado: (2023)

Expression of Adenosine Receptors in Rodent Pancreas
por: Hayashi, Mikio
Publicado: (2019)

Amyotrophic Lateral Sclerosis (ALS) and Adenosine Receptors
por: Sebastião, Ana M., et al.
Publicado: (2018)

Targeting Adenosine Receptors for the Treatment of Cardiac Fibrosis
por: Vecchio, Elizabeth A., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_7m8k90kngp700q12krtpnmdekp