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Exercise modes and their association with hypoglycemia episodes in adults with type 1 diabetes mellitus: a systematic review
OBJECTIVE: Type 1 diabetes mellitus rates are rising worldwide. The health benefits of physical exercise in this condition are many, but more than 60% do not participate, mainly from fear of hypoglycemia. This systematic review explores the effects of physical exercise modes on blood glucose levels...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203053/ https://www.ncbi.nlm.nih.gov/pubmed/30397494 http://dx.doi.org/10.1136/bmjdrc-2018-000578 |
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author | Hasan, Saima Shaw, Sian M Gelling, Leslie H Kerr, Catherine J Meads, Catherine A |
author_facet | Hasan, Saima Shaw, Sian M Gelling, Leslie H Kerr, Catherine J Meads, Catherine A |
author_sort | Hasan, Saima |
collection | PubMed |
description | OBJECTIVE: Type 1 diabetes mellitus rates are rising worldwide. The health benefits of physical exercise in this condition are many, but more than 60% do not participate, mainly from fear of hypoglycemia. This systematic review explores the effects of physical exercise modes on blood glucose levels in adults for hypoglycemia prevention. RESEARCH DESIGN AND METHODS: Predefined inclusion criteria were randomized or non-randomized cross-over trials of healthy non-obese adults with type 1 diabetes mellitus. Exercise interventions used standardized protocols of intensity and timing. Outcomes included hypoglycemia during or after exercise, and acute glycemic control. Medline, Cumulative Index to Nursing and Allied Health Literature, Allied and Complementary Medicine Database, SPORTDiscus, CochraneCENTRAL (1990 to 11 January 2018), and Embase (1988 to 9 April 2018) were searched using keywords and Medical Subject Heading (MeSH) terms. Inclusions, data extraction and quality assessment using the Critical Appraisal Skills Programme checklists were done by one researcher and checked by a second. Review Manager (V.5.3) was used for meta-analysis where four or more outcomes were reported. RESULTS: From 5459 citations, we included 15 small cross-over studies (3 non-randomized), 13 assessing aerobic (intermittent high-intensity exercise (IHE) vs continuous, or continuous vs rest) and 2 assessing resistance exercise versus rest. Study quality was good, and all outcome measures were reported. Thirteen gave hypoglycemia results, of which five had no episodes. Meta-analysis of hypoglycemia during or after IHE compared with continuous exercise showed no significant differences (n=5, OR=0.68 (95% CI 0.16 to 2.86), I(2)=56%). For blood glucose there was little difference between groups at any time point. CONCLUSION: IHE may be safer than continuous exercise because of lesser decline in blood glucose, but more research needs to demonstrate if this would be reflected in hypoglycemic episode rates. TRIAL REGISTRATION NUMBER: CRD42018068358. |
format | Online Article Text |
id | pubmed-6203053 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-62030532018-11-05 Exercise modes and their association with hypoglycemia episodes in adults with type 1 diabetes mellitus: a systematic review Hasan, Saima Shaw, Sian M Gelling, Leslie H Kerr, Catherine J Meads, Catherine A BMJ Open Diabetes Res Care Clinical Care/Education/Nutrition OBJECTIVE: Type 1 diabetes mellitus rates are rising worldwide. The health benefits of physical exercise in this condition are many, but more than 60% do not participate, mainly from fear of hypoglycemia. This systematic review explores the effects of physical exercise modes on blood glucose levels in adults for hypoglycemia prevention. RESEARCH DESIGN AND METHODS: Predefined inclusion criteria were randomized or non-randomized cross-over trials of healthy non-obese adults with type 1 diabetes mellitus. Exercise interventions used standardized protocols of intensity and timing. Outcomes included hypoglycemia during or after exercise, and acute glycemic control. Medline, Cumulative Index to Nursing and Allied Health Literature, Allied and Complementary Medicine Database, SPORTDiscus, CochraneCENTRAL (1990 to 11 January 2018), and Embase (1988 to 9 April 2018) were searched using keywords and Medical Subject Heading (MeSH) terms. Inclusions, data extraction and quality assessment using the Critical Appraisal Skills Programme checklists were done by one researcher and checked by a second. Review Manager (V.5.3) was used for meta-analysis where four or more outcomes were reported. RESULTS: From 5459 citations, we included 15 small cross-over studies (3 non-randomized), 13 assessing aerobic (intermittent high-intensity exercise (IHE) vs continuous, or continuous vs rest) and 2 assessing resistance exercise versus rest. Study quality was good, and all outcome measures were reported. Thirteen gave hypoglycemia results, of which five had no episodes. Meta-analysis of hypoglycemia during or after IHE compared with continuous exercise showed no significant differences (n=5, OR=0.68 (95% CI 0.16 to 2.86), I(2)=56%). For blood glucose there was little difference between groups at any time point. CONCLUSION: IHE may be safer than continuous exercise because of lesser decline in blood glucose, but more research needs to demonstrate if this would be reflected in hypoglycemic episode rates. TRIAL REGISTRATION NUMBER: CRD42018068358. BMJ Publishing Group 2018-10-08 /pmc/articles/PMC6203053/ /pubmed/30397494 http://dx.doi.org/10.1136/bmjdrc-2018-000578 Text en © Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Clinical Care/Education/Nutrition Hasan, Saima Shaw, Sian M Gelling, Leslie H Kerr, Catherine J Meads, Catherine A Exercise modes and their association with hypoglycemia episodes in adults with type 1 diabetes mellitus: a systematic review |
title | Exercise modes and their association with hypoglycemia episodes in adults with type 1 diabetes mellitus: a systematic review |
title_full | Exercise modes and their association with hypoglycemia episodes in adults with type 1 diabetes mellitus: a systematic review |
title_fullStr | Exercise modes and their association with hypoglycemia episodes in adults with type 1 diabetes mellitus: a systematic review |
title_full_unstemmed | Exercise modes and their association with hypoglycemia episodes in adults with type 1 diabetes mellitus: a systematic review |
title_short | Exercise modes and their association with hypoglycemia episodes in adults with type 1 diabetes mellitus: a systematic review |
title_sort | exercise modes and their association with hypoglycemia episodes in adults with type 1 diabetes mellitus: a systematic review |
topic | Clinical Care/Education/Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203053/ https://www.ncbi.nlm.nih.gov/pubmed/30397494 http://dx.doi.org/10.1136/bmjdrc-2018-000578 |
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