Cargando…
Prognostic value of NEK2 overexpression in digestive system cancers: a meta-analysis and systematic review
BACKGROUND AND OBJECTIVE: Many studies have reported that NEK2 is overexpressed in digestive system cancers (DSCs) and is also correlated with patient survival. We performed a meta-analysis to comprehensively evaluate the prognostic role of NEK2 expression in DSCs. MATERIALS AND METHODS: A comprehen...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203090/ https://www.ncbi.nlm.nih.gov/pubmed/30425509 http://dx.doi.org/10.2147/OTT.S169911 |
_version_ | 1783365808635772928 |
---|---|
author | Ren, Qian Li, Bowen Liu, Min Hu, Zenan Wang, Yuping |
author_facet | Ren, Qian Li, Bowen Liu, Min Hu, Zenan Wang, Yuping |
author_sort | Ren, Qian |
collection | PubMed |
description | BACKGROUND AND OBJECTIVE: Many studies have reported that NEK2 is overexpressed in digestive system cancers (DSCs) and is also correlated with patient survival. We performed a meta-analysis to comprehensively evaluate the prognostic role of NEK2 expression in DSCs. MATERIALS AND METHODS: A comprehensive literature search was performed using PubMed, EMBASE, and Web of Science. Synthesized hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the influence of NEK2 overexpression on the prognosis and clinicopathological features of patients with DSCs. RESULTS: A total of 13 studies involving 1,917 patients was included. Overall, patients with high NEK2 expression had poorer overall survival (HR =1.45; 95% CI: 1.15–1.83; P=0.002) and disease-free survival/recurrence-free survival (HR =2.28; 95% CI: 1.54–3.37; P<0.0001). Furthermore, subgroup analysis also suggested that elevated NEK2 expression was associated with poorer overall survival in patients with hepatocellular carcinoma (HR =1.45; 95% CI: 1.05–2.00; P=0.02) and colorectal cancer (HR =2.03; 95% CI: 1.16–3.54; P=0.01). Additionally, NEK2 overexpression was also associated with pretreatment serum AFP level (OR =1.79; 95% CI: 1.23–2.61; P<0.01) and portal vein thrombosis (OR =2.74; 95% CI: 1.22–6.17; P=0.01) in hepatocellular carcinoma. CONCLUSION: NEK2 might act as a useful prognostic predictor and a potential therapeutic target in DSCs. However, multicenter homogeneous studies with larger sample sizes are needed to further confirm our findings owing to some limitations in our meta-analysis. |
format | Online Article Text |
id | pubmed-6203090 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-62030902018-11-13 Prognostic value of NEK2 overexpression in digestive system cancers: a meta-analysis and systematic review Ren, Qian Li, Bowen Liu, Min Hu, Zenan Wang, Yuping Onco Targets Ther Original Research BACKGROUND AND OBJECTIVE: Many studies have reported that NEK2 is overexpressed in digestive system cancers (DSCs) and is also correlated with patient survival. We performed a meta-analysis to comprehensively evaluate the prognostic role of NEK2 expression in DSCs. MATERIALS AND METHODS: A comprehensive literature search was performed using PubMed, EMBASE, and Web of Science. Synthesized hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the influence of NEK2 overexpression on the prognosis and clinicopathological features of patients with DSCs. RESULTS: A total of 13 studies involving 1,917 patients was included. Overall, patients with high NEK2 expression had poorer overall survival (HR =1.45; 95% CI: 1.15–1.83; P=0.002) and disease-free survival/recurrence-free survival (HR =2.28; 95% CI: 1.54–3.37; P<0.0001). Furthermore, subgroup analysis also suggested that elevated NEK2 expression was associated with poorer overall survival in patients with hepatocellular carcinoma (HR =1.45; 95% CI: 1.05–2.00; P=0.02) and colorectal cancer (HR =2.03; 95% CI: 1.16–3.54; P=0.01). Additionally, NEK2 overexpression was also associated with pretreatment serum AFP level (OR =1.79; 95% CI: 1.23–2.61; P<0.01) and portal vein thrombosis (OR =2.74; 95% CI: 1.22–6.17; P=0.01) in hepatocellular carcinoma. CONCLUSION: NEK2 might act as a useful prognostic predictor and a potential therapeutic target in DSCs. However, multicenter homogeneous studies with larger sample sizes are needed to further confirm our findings owing to some limitations in our meta-analysis. Dove Medical Press 2018-10-18 /pmc/articles/PMC6203090/ /pubmed/30425509 http://dx.doi.org/10.2147/OTT.S169911 Text en © 2018 Ren et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Ren, Qian Li, Bowen Liu, Min Hu, Zenan Wang, Yuping Prognostic value of NEK2 overexpression in digestive system cancers: a meta-analysis and systematic review |
title | Prognostic value of NEK2 overexpression in digestive system cancers: a meta-analysis and systematic review |
title_full | Prognostic value of NEK2 overexpression in digestive system cancers: a meta-analysis and systematic review |
title_fullStr | Prognostic value of NEK2 overexpression in digestive system cancers: a meta-analysis and systematic review |
title_full_unstemmed | Prognostic value of NEK2 overexpression in digestive system cancers: a meta-analysis and systematic review |
title_short | Prognostic value of NEK2 overexpression in digestive system cancers: a meta-analysis and systematic review |
title_sort | prognostic value of nek2 overexpression in digestive system cancers: a meta-analysis and systematic review |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203090/ https://www.ncbi.nlm.nih.gov/pubmed/30425509 http://dx.doi.org/10.2147/OTT.S169911 |
work_keys_str_mv | AT renqian prognosticvalueofnek2overexpressionindigestivesystemcancersametaanalysisandsystematicreview AT libowen prognosticvalueofnek2overexpressionindigestivesystemcancersametaanalysisandsystematicreview AT liumin prognosticvalueofnek2overexpressionindigestivesystemcancersametaanalysisandsystematicreview AT huzenan prognosticvalueofnek2overexpressionindigestivesystemcancersametaanalysisandsystematicreview AT wangyuping prognosticvalueofnek2overexpressionindigestivesystemcancersametaanalysisandsystematicreview |