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Prediction of Hot Spots at Myeloid Cell Leukemia-1–Inhibitor Interface Using Energy Estimation and Alanine Scanning Mutagenesis

[Image: see text] Myeloid cell leukemia 1 (Mcl1) is an antiapoptotic protein that plays central role in apoptosis regulation. Also, Mcl1 has the potency to resist apoptotic cues resulting in up-regulation and cancer cell protection. A molecular probe that has the potential to specifically target Mcl...

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Detalles Bibliográficos
Autores principales:	Marimuthu, Parthiban, Singaravelu, Kalaimathy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203182/ https://www.ncbi.nlm.nih.gov/pubmed/29345906 http://dx.doi.org/10.1021/acs.biochem.7b01048

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