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Association between the prevalence of hyperuricemia and reproductive hormones in polycystic ovary syndrome

BACKGROUND: The prevalecne of hyperuricemia in polycystic ovary syndrome (PCOS) is still uncertain. We aimed to investigate the prevalence of hyperuricemia in PCOS and to determine the influence of reproductive hormones on uric acid concentration. METHODS: This retrospective cross-sectional study wa...

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Autores principales: Mu, Liangshan, Pan, Jiexue, Yang, Lili, Chen, Qianqian, Chen, Ya, Teng, Yili, Wang, Peiyu, Tang, Rong, Huang, Xuefeng, Chen, Xia, Yang, Haiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203189/
https://www.ncbi.nlm.nih.gov/pubmed/30359269
http://dx.doi.org/10.1186/s12958-018-0419-x
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author Mu, Liangshan
Pan, Jiexue
Yang, Lili
Chen, Qianqian
Chen, Ya
Teng, Yili
Wang, Peiyu
Tang, Rong
Huang, Xuefeng
Chen, Xia
Yang, Haiyan
author_facet Mu, Liangshan
Pan, Jiexue
Yang, Lili
Chen, Qianqian
Chen, Ya
Teng, Yili
Wang, Peiyu
Tang, Rong
Huang, Xuefeng
Chen, Xia
Yang, Haiyan
author_sort Mu, Liangshan
collection PubMed
description BACKGROUND: The prevalecne of hyperuricemia in polycystic ovary syndrome (PCOS) is still uncertain. We aimed to investigate the prevalence of hyperuricemia in PCOS and to determine the influence of reproductive hormones on uric acid concentration. METHODS: This retrospective cross-sectional study was performed at a large reproductive medicine center. Between March 2007 and October 2016, a total of 1,183 women with PCOS and 10,772 women without PCOS were included. PCOS was diagnosed according to the Rotterdam criteria. Anthropometric parameters, blood pressure, uric acid, reproductive hormones, glucose and lipids were measured in all subjects. RESULTS: The serum uric acid (SUA) level was higher in women with PCOS than in women without PCOS. The prevalence of hyperuricemia in women with PCOS (25.48%) was significantly higher than that in women without PCOS (8.74%). Analysis stratified for age and body mass index (BMI) showed that both the SUA level and the prevalence of hyperuricemia were higher in women with PCOS of different age and BMI groups than in women without PCOS. After adjusting for age, BMI and estimated glomerular filtration rate (eGFR), logistic regression analysis revealed that the luteinizing/follicle-stimulating hormone (LH/FSH) ratio (odds ratio (OR) = 1.20, 95% CI = 1.01–1.43) and testosterone level (OR = 1.56, 95% CI = 1.27–1.90) were positively associated with the prevalence of hyperuricemia in females with PCOS. CONCLUSIONS: The serum uric acid (SUA) level and the prevalence of hyperuricemia markedly increased in women with PCOS. The testosterone level was positively associated with the SUA level and the prevalence of hyperuricemia in females with PCOS.
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spelling pubmed-62031892018-11-01 Association between the prevalence of hyperuricemia and reproductive hormones in polycystic ovary syndrome Mu, Liangshan Pan, Jiexue Yang, Lili Chen, Qianqian Chen, Ya Teng, Yili Wang, Peiyu Tang, Rong Huang, Xuefeng Chen, Xia Yang, Haiyan Reprod Biol Endocrinol Research BACKGROUND: The prevalecne of hyperuricemia in polycystic ovary syndrome (PCOS) is still uncertain. We aimed to investigate the prevalence of hyperuricemia in PCOS and to determine the influence of reproductive hormones on uric acid concentration. METHODS: This retrospective cross-sectional study was performed at a large reproductive medicine center. Between March 2007 and October 2016, a total of 1,183 women with PCOS and 10,772 women without PCOS were included. PCOS was diagnosed according to the Rotterdam criteria. Anthropometric parameters, blood pressure, uric acid, reproductive hormones, glucose and lipids were measured in all subjects. RESULTS: The serum uric acid (SUA) level was higher in women with PCOS than in women without PCOS. The prevalence of hyperuricemia in women with PCOS (25.48%) was significantly higher than that in women without PCOS (8.74%). Analysis stratified for age and body mass index (BMI) showed that both the SUA level and the prevalence of hyperuricemia were higher in women with PCOS of different age and BMI groups than in women without PCOS. After adjusting for age, BMI and estimated glomerular filtration rate (eGFR), logistic regression analysis revealed that the luteinizing/follicle-stimulating hormone (LH/FSH) ratio (odds ratio (OR) = 1.20, 95% CI = 1.01–1.43) and testosterone level (OR = 1.56, 95% CI = 1.27–1.90) were positively associated with the prevalence of hyperuricemia in females with PCOS. CONCLUSIONS: The serum uric acid (SUA) level and the prevalence of hyperuricemia markedly increased in women with PCOS. The testosterone level was positively associated with the SUA level and the prevalence of hyperuricemia in females with PCOS. BioMed Central 2018-10-25 /pmc/articles/PMC6203189/ /pubmed/30359269 http://dx.doi.org/10.1186/s12958-018-0419-x Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Mu, Liangshan
Pan, Jiexue
Yang, Lili
Chen, Qianqian
Chen, Ya
Teng, Yili
Wang, Peiyu
Tang, Rong
Huang, Xuefeng
Chen, Xia
Yang, Haiyan
Association between the prevalence of hyperuricemia and reproductive hormones in polycystic ovary syndrome
title Association between the prevalence of hyperuricemia and reproductive hormones in polycystic ovary syndrome
title_full Association between the prevalence of hyperuricemia and reproductive hormones in polycystic ovary syndrome
title_fullStr Association between the prevalence of hyperuricemia and reproductive hormones in polycystic ovary syndrome
title_full_unstemmed Association between the prevalence of hyperuricemia and reproductive hormones in polycystic ovary syndrome
title_short Association between the prevalence of hyperuricemia and reproductive hormones in polycystic ovary syndrome
title_sort association between the prevalence of hyperuricemia and reproductive hormones in polycystic ovary syndrome
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203189/
https://www.ncbi.nlm.nih.gov/pubmed/30359269
http://dx.doi.org/10.1186/s12958-018-0419-x
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