Establishment of a rapid and footprint-free protocol for differentiation of human embryonic stem cells into pancreatic endocrine cells with synthetic mRNAs encoding transcription factors

BACKGROUND: Transplantation of pancreatic β cells generated in vitro from pluripotent stem cells (hPSCs) such as embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) has been proposed as an alternative therapy for diabetes. Though many differentiation protocols have been developed f...

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Detalles Bibliográficos
Autores principales: Ida, Hideomi, Akiyama, Tomohiko, Ishiguro, Keiichiro, Goparaju, Sravan K., Nakatake, Yuhki, Chikazawa-Nohtomi, Nana, Sato, Saeko, Kimura, Hiromi, Yokoyama, Yukihiro, Nagino, Masato, Ko, Minoru S. H., Ko, Shigeru B. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203190/
https://www.ncbi.nlm.nih.gov/pubmed/30359326
http://dx.doi.org/10.1186/s13287-018-1038-3

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