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MR-based spatial normalization improves [(18)F]MNI-659 PET regional quantification and detectability of disease effect in the Q175 mouse model of Huntington’s disease

The positron emission tomography (PET) tracer [(18)F]MNI-659, selective for phosphodiesterase 10A (PDE10A), is a promising tool to assess an early biomarker for Huntington’s disease (HD). In this study we investigated [(18)F]MNI-659 uptake in the Q175 mouse model of HD. Given the focal striatal dist...

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Detalles Bibliográficos
Autores principales:	Bertoglio, Daniele, Verhaeghe, Jeroen, Kosten, Lauren, Thomae, David, Van der Linden, Annemie, Stroobants, Sigrid, Wityak, John, Dominguez, Celia, Mrzljak, Ladislav, Staelens, Steven
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203386/ https://www.ncbi.nlm.nih.gov/pubmed/30365550 http://dx.doi.org/10.1371/journal.pone.0206613

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