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Diagnostic value of ultrasonography in synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome: A case report

RATIONALE: Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is a rare condition that affects the skin, bones, and joints. Diagnosis of SAPHO syndrome is established based on clinical manifestations and imaging features on radiography or magnetic resonance imaging. PATIENT CONCERNS: W...

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Autores principales: Asano, Tomoyuki, Furuya, Makiko Yashiro, Fujita, Yuya, Matsuoka, Naoki, Sato, Shuzo, Kobayashi, Hiroko, Watanabe, Hiroshi, Honda, Aki, Migita, Kiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203473/
https://www.ncbi.nlm.nih.gov/pubmed/30313072
http://dx.doi.org/10.1097/MD.0000000000012725
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author Asano, Tomoyuki
Furuya, Makiko Yashiro
Fujita, Yuya
Matsuoka, Naoki
Sato, Shuzo
Kobayashi, Hiroko
Watanabe, Hiroshi
Honda, Aki
Migita, Kiyoshi
author_facet Asano, Tomoyuki
Furuya, Makiko Yashiro
Fujita, Yuya
Matsuoka, Naoki
Sato, Shuzo
Kobayashi, Hiroko
Watanabe, Hiroshi
Honda, Aki
Migita, Kiyoshi
author_sort Asano, Tomoyuki
collection PubMed
description RATIONALE: Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is a rare condition that affects the skin, bones, and joints. Diagnosis of SAPHO syndrome is established based on clinical manifestations and imaging features on radiography or magnetic resonance imaging. PATIENT CONCERNS: We report a 44-year-old male with a 20-year history of pustulosis who presented with pain in the lower extremities. Plain radiography demonstrated hyperostosis with subperiosteal erosions in the right tibia. Magnetic resonance imaging and computed tomography showed inflammatory accumulation, whereas musculoskeletal ultrasonography clearly depicted a periosteal reaction, osteitis, and enthesitis with abnormal blood flow in the surface of the right tibia. DIAGNOSES: A diagnosis of SAPHO syndrome was made. INTERVENTIONS: The patient was treated with combination therapy comprising prednisolone, methotrexate, and infliximab, which resulted in clinical improvement. OUTCOMES: The elevated levels of C-reactive protein and matrix metalloproteinase-3 normalized, and the abnormal ultrasonographic findings disappeared. LESSONS: The present case report demonstrates that multiple imaging modalities are important for the definitive diagnosis of SAPHO syndrome. Ultrasonography might be a useful tool for evaluating local musculoskeletal inflammation in patients with SAPHO syndrome.
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spelling pubmed-62034732018-11-07 Diagnostic value of ultrasonography in synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome: A case report Asano, Tomoyuki Furuya, Makiko Yashiro Fujita, Yuya Matsuoka, Naoki Sato, Shuzo Kobayashi, Hiroko Watanabe, Hiroshi Honda, Aki Migita, Kiyoshi Medicine (Baltimore) Research Article RATIONALE: Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is a rare condition that affects the skin, bones, and joints. Diagnosis of SAPHO syndrome is established based on clinical manifestations and imaging features on radiography or magnetic resonance imaging. PATIENT CONCERNS: We report a 44-year-old male with a 20-year history of pustulosis who presented with pain in the lower extremities. Plain radiography demonstrated hyperostosis with subperiosteal erosions in the right tibia. Magnetic resonance imaging and computed tomography showed inflammatory accumulation, whereas musculoskeletal ultrasonography clearly depicted a periosteal reaction, osteitis, and enthesitis with abnormal blood flow in the surface of the right tibia. DIAGNOSES: A diagnosis of SAPHO syndrome was made. INTERVENTIONS: The patient was treated with combination therapy comprising prednisolone, methotrexate, and infliximab, which resulted in clinical improvement. OUTCOMES: The elevated levels of C-reactive protein and matrix metalloproteinase-3 normalized, and the abnormal ultrasonographic findings disappeared. LESSONS: The present case report demonstrates that multiple imaging modalities are important for the definitive diagnosis of SAPHO syndrome. Ultrasonography might be a useful tool for evaluating local musculoskeletal inflammation in patients with SAPHO syndrome. Wolters Kluwer Health 2018-10-12 /pmc/articles/PMC6203473/ /pubmed/30313072 http://dx.doi.org/10.1097/MD.0000000000012725 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Research Article
Asano, Tomoyuki
Furuya, Makiko Yashiro
Fujita, Yuya
Matsuoka, Naoki
Sato, Shuzo
Kobayashi, Hiroko
Watanabe, Hiroshi
Honda, Aki
Migita, Kiyoshi
Diagnostic value of ultrasonography in synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome: A case report
title Diagnostic value of ultrasonography in synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome: A case report
title_full Diagnostic value of ultrasonography in synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome: A case report
title_fullStr Diagnostic value of ultrasonography in synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome: A case report
title_full_unstemmed Diagnostic value of ultrasonography in synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome: A case report
title_short Diagnostic value of ultrasonography in synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome: A case report
title_sort diagnostic value of ultrasonography in synovitis-acne-pustulosis-hyperostosis-osteitis (sapho) syndrome: a case report
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203473/
https://www.ncbi.nlm.nih.gov/pubmed/30313072
http://dx.doi.org/10.1097/MD.0000000000012725
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