Cargando…

Gene therapy knockdown of VEGFR2 in retinal endothelial cells to treat retinopathy

Inhibition of vascular endothelial growth factor (VEGF) in retinopathy of prematurity (ROP) raises concerns for premature infants because VEGF is essential for retinovascular development as well as neuronal and glial health. This study tested the hypothesis that endothelial cell-specific knockdown o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Simmons, Aaron B., Bretz, Colin A., Wang, Haibo, Kunz, Eric, Hajj, Kassem, Kennedy, Carson, Yang, Zhihong, Suwanmanee, Thipparat, Kafri, Tal, Hartnett, M. Elizabeth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Netherlands 2018
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203654/ https://www.ncbi.nlm.nih.gov/pubmed/29730824 http://dx.doi.org/10.1007/s10456-018-9618-5

Ejemplares similares

Correction to: Gene therapy knockdown of VEGFR2 in retinal endothelial cells to treat retinopathy
por: Simmons, Aaron B., et al.
Publicado: (2018)

Targeted Knockdown of Overexpressed VEGFA or VEGF164 in Müller cells maintains retinal function by triggering different signaling mechanisms
por: Becker, Silke, et al.
Publicado: (2018)

RNA-Seq Provides Insights into VEGF-Induced Signaling in Human Retinal Microvascular Endothelial Cells: Implications in Retinopathy of Prematurity
por: Ramshekar, Aniket, et al.
Publicado: (2022)

Toward Personalized Gene Therapy: Characterizing the Host Genetic Control of Lentiviral-Vector-Mediated Hepatic Gene Delivery
por: Suwanmanee, Thipparat, et al.
Publicado: (2017)

Superior lentiviral vectors designed for BSL-0 environment abolish vector mobilization.
por: Hu, Peirong, et al.
Publicado: (2018)

Enhancing Retinal Endothelial Glycolysis by Inhibiting UCP2 Promotes Physiologic Retinal Vascular Development in a Model of Retinopathy of Prematurity
por: Han, Xiaokun, et al.
Publicado: (2019)

Endothelial NADPH oxidase 4 mediates vascular endothelial growth factor receptor 2–induced intravitreal neovascularization in a rat model of retinopathy of prematurity
por: Wang, Haibo, et al.
Publicado: (2014)

Erythropoietin Signaling Increases Choroidal Macrophages and Cytokine Expression, and Exacerbates Choroidal Neovascularization
por: Bretz, Colin A., et al.
Publicado: (2018)

Signaling Through the Erythropoietin Receptor Affects Angiogenesis in Retinovascular Disease
por: Bretz, Colin A., et al.
Publicado: (2020)

Retinopathy of prematurity protection conferred by uteroplacental insufficiency through erythropoietin signaling in an experimental Murine Model
por: Fung, Camille, et al.
Publicado: (2023)

Knockdown of VEGFR2 Inhibits Proliferation and Induces Apoptosis in Hemangioma-Derived Endothelial Cells
por: Ou, J.M., et al.
Publicado: (2014)

Effect of subretinal injection on retinal structure and function in a rat oxygen-induced retinopathy model
por: Becker, Silke, et al.
Publicado: (2017)

Role of Erythropoietin Receptor Signaling in Macrophages or Choroidal Endothelial Cells in Choroidal Neovascularization
por: Ramshekar, Aniket, et al.
Publicado: (2022)

Automatic analysis of the retinal avascular area in the rat oxygen-induced retinopathy model
por: Simmons, Michael A., et al.
Publicado: (2018)

Vascular Endothelial Growth Factor Signaling in Models of Oxygen-Induced Retinopathy: Insights Into Mechanisms of Pathology in Retinopathy of Prematurity
por: Ramshekar, Aniket, et al.
Publicado: (2021)

Thy-1 Regulates VEGF-Mediated Choroidal Endothelial Cell Activation and Migration: Implications in Neovascular Age-Related Macular Degeneration
por: Wang, Haibo, et al.
Publicado: (2016)

Retinal Inhibition of CCR3 Induces Retinal Cell Death in a Murine Model of Choroidal Neovascularization
por: Wang, Haibo, et al.
Publicado: (2016)

Blood Vessel Patterning on Retinal Astrocytes Requires Endothelial Flt-1 (VEGFR-1)
por: Chappell, John C., et al.
Publicado: (2019)

RNA-Seq Reveals a Role for NFAT-Signaling in Human Retinal Microvascular Endothelial Cells Treated with TNFα
por: Savage, Sara R., et al.
Publicado: (2015)

Expression of vascular endothelial growth factor and pigment epithelial-derived factor in a rat model of retinopathy of prematurity
por: Hartmann, John S., et al.
Publicado: (2011)

Author Correction: Endomucin knockdown inhibits VEGF-induced endothelial cell migration, growth, and morphogenesis by modulating VEGFR2 signaling
por: Park-Windhol, Cindy, et al.
Publicado: (2023)

Retinal pigment epithelial cell expression of active Rap 1a by scAAV2 inhibits choroidal neovascularization
por: Wang, Haibo, et al.
Publicado: (2016)

VEGFR1 signaling in retinal angiogenesis and microinflammation
por: Uemura, Akiyoshi, et al.
Publicado: (2021)

Distinct transcriptional responses of lymphatic endothelial cells to VEGFR-3 and VEGFR-2 stimulation
por: Dieterich, Lothar C., et al.
Publicado: (2017)

Employing a Gain-of-Function Factor IX Variant R338L to Advance the Efficacy and Safety of Hemophilia B Human Gene Therapy: Preclinical Evaluation Supporting an Ongoing Adeno-Associated Virus Clinical Trial
por: Monahan, Paul E., et al.
Publicado: (2015)

Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex
por: Coon, Brian G., et al.
Publicado: (2015)

The Effects of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase and Erythropoietin, and Their Interactions in Angiogenesis: Implications in Retinopathy of Prematurity
por: Cung, Thaonhi, et al.
Publicado: (2022)

Effects of oestradiol and tamoxifen on VEGF, soluble VEGFR-1, and VEGFR-2 in breast cancer and endothelial cells
por: Garvin, S, et al.
Publicado: (2005)

Knockdown of Fibromodulin Inhibits Proliferation and Migration of RPE Cell via the VEGFR2-AKT Pathway
por: Hu, He, et al.
Publicado: (2018)

Predicting Angiogenesis by Endothelial Progenitor Cells Relying on In-Vitro Function Assays and VEGFR-2 Expression Levels
por: Sabbah, Nadin, et al.
Publicado: (2019)

The Prognostic Value of the Combination of Low VEGFR-1 and High VEGFR-2 Expression in Endothelial Cells of Colorectal Cancer
por: D’Haene, Nicky, et al.
Publicado: (2018)

Knockdown of VEGFB/VEGFR1 Signaling Promotes White Adipose Tissue Browning and Skeletal Muscle Development
por: Ling, Mingfa, et al.
Publicado: (2022)

Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin
por: Smith, Ross O, et al.
Publicado: (2020)

VEGFR2 regulates endothelial differentiation of colon cancer cells
por: Liu, Zhiyong, et al.
Publicado: (2017)

Decursin inhibits retinal neovascularization via suppression of VEGFR-2 activation
por: Kim, Jeong Hun, et al.
Publicado: (2009)

Vascular endothelial growth factor and its soluble receptors VEGFR-1 and VEGFR-2 in the serum of patients with systemic lupus erythematosus.
por: Robak, Ewa, et al.
Publicado: (2003)

Regulation of Rac1 Activation in Choroidal Endothelial Cells: Insights into Mechanisms in Age-Related Macular Degeneration
por: Ramshekar, Aniket, et al.
Publicado: (2021)

Current Concepts of Oxygen Management in Retinopathy of Prematurity
por: Owen, Leah A., et al.
Publicado: (2014)

Elevated expression of VEGFR-3 in lymphatic endothelial cells from lymphangiomas
por: Norgall, Susanne, et al.
Publicado: (2007)

Multi-physics interactions drive VEGFR2 relocation on endothelial cells
por: Damioli, Valentina, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_um1u1u0qjhid5nof84picgvov3