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Common helical V1V2 conformations of HIV-1 Envelope expose the α4β7 binding site on intact virions

The α4β7 integrin is a non-essential HIV-1 adhesion receptor, bound by the gp120 V1V2 domain, facilitating rapid viral dissemination into gut-associated lymphoid tissues. Antibodies blocking this interaction early in infection can improve disease outcome, and V1V2-targeted antibodies were correlated...

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Detalles Bibliográficos
Autores principales:	Wibmer, Constantinos Kurt, Richardson, Simone I., Yolitz, Jason, Cicala, Claudia, Arthos, James, Moore, Penny L., Morris, Lynn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203816/ https://www.ncbi.nlm.nih.gov/pubmed/30367034 http://dx.doi.org/10.1038/s41467-018-06794-x

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