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Waist circumference and risk of 23 site-specific cancers: a population-based cohort study of Korean adults

BACKGROUND: Large waist circumference (WC) is a risk factor for several site-specific cancers, but a large-scale systematic investigation across all common cancers adjusted for potential confounders has not been conducted. This study aimed to evaluate the possible links between WC and common cancers...

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Autores principales: Lee, Kyu Rae, Seo, Mi Hae, Do Han, Kyung, Jung, Jinhyung, Hwang, In Cheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203821/
https://www.ncbi.nlm.nih.gov/pubmed/30327562
http://dx.doi.org/10.1038/s41416-018-0214-7
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author Lee, Kyu Rae
Seo, Mi Hae
Do Han, Kyung
Jung, Jinhyung
Hwang, In Cheol
author_facet Lee, Kyu Rae
Seo, Mi Hae
Do Han, Kyung
Jung, Jinhyung
Hwang, In Cheol
author_sort Lee, Kyu Rae
collection PubMed
description BACKGROUND: Large waist circumference (WC) is a risk factor for several site-specific cancers, but a large-scale systematic investigation across all common cancers adjusted for potential confounders has not been conducted. This study aimed to evaluate the possible links between WC and common cancers. METHODS: We prospectively examined the association between WC and the risk of cancers in a 7-year cohort study of nearly 22.9 million Korean adults. Using the claims database merged with the national health check-up data, we fitted proportional hazard models to investigate associations between WC and 23 of the most common cancers, with adjustment for potential confounders, including body mass index (BMI). We also evaluated the modification of BMI on the relationships between WC and the incidence of cancer. RESULTS: A total of 769,871 cancer cases were identified. WC was positively associated with 18 of 23 cancers, and the effects varied substantially by site in each sex. The modification of BMI on the WC-cancer association also varied across the cancer site; in most cases it mitigated the association. For cancers of the oral cavity, larynx, oesophagus, lung, and premenopausal breast, the BMI adjustment reversed the association toward being positive (all P(trend) < 0.001). CONCLUSIONS: Central obesity, independent of general obesity, was associated with the risk of several cancers. The heterogeneity in the mediating effects of BMI suggests that different mechanisms are associated with different cancer sites. Based upon these findings, active strategies to monitor and prevent central obesity should be implemented.
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spelling pubmed-62038212019-10-17 Waist circumference and risk of 23 site-specific cancers: a population-based cohort study of Korean adults Lee, Kyu Rae Seo, Mi Hae Do Han, Kyung Jung, Jinhyung Hwang, In Cheol Br J Cancer Article BACKGROUND: Large waist circumference (WC) is a risk factor for several site-specific cancers, but a large-scale systematic investigation across all common cancers adjusted for potential confounders has not been conducted. This study aimed to evaluate the possible links between WC and common cancers. METHODS: We prospectively examined the association between WC and the risk of cancers in a 7-year cohort study of nearly 22.9 million Korean adults. Using the claims database merged with the national health check-up data, we fitted proportional hazard models to investigate associations between WC and 23 of the most common cancers, with adjustment for potential confounders, including body mass index (BMI). We also evaluated the modification of BMI on the relationships between WC and the incidence of cancer. RESULTS: A total of 769,871 cancer cases were identified. WC was positively associated with 18 of 23 cancers, and the effects varied substantially by site in each sex. The modification of BMI on the WC-cancer association also varied across the cancer site; in most cases it mitigated the association. For cancers of the oral cavity, larynx, oesophagus, lung, and premenopausal breast, the BMI adjustment reversed the association toward being positive (all P(trend) < 0.001). CONCLUSIONS: Central obesity, independent of general obesity, was associated with the risk of several cancers. The heterogeneity in the mediating effects of BMI suggests that different mechanisms are associated with different cancer sites. Based upon these findings, active strategies to monitor and prevent central obesity should be implemented. Nature Publishing Group UK 2018-10-17 2018-10-16 /pmc/articles/PMC6203821/ /pubmed/30327562 http://dx.doi.org/10.1038/s41416-018-0214-7 Text en © Cancer Research UK 2018 https://creativecommons.org/licenses/by/4.0/This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution 4.0 International (CC BY 4.0).
spellingShingle Article
Lee, Kyu Rae
Seo, Mi Hae
Do Han, Kyung
Jung, Jinhyung
Hwang, In Cheol
Waist circumference and risk of 23 site-specific cancers: a population-based cohort study of Korean adults
title Waist circumference and risk of 23 site-specific cancers: a population-based cohort study of Korean adults
title_full Waist circumference and risk of 23 site-specific cancers: a population-based cohort study of Korean adults
title_fullStr Waist circumference and risk of 23 site-specific cancers: a population-based cohort study of Korean adults
title_full_unstemmed Waist circumference and risk of 23 site-specific cancers: a population-based cohort study of Korean adults
title_short Waist circumference and risk of 23 site-specific cancers: a population-based cohort study of Korean adults
title_sort waist circumference and risk of 23 site-specific cancers: a population-based cohort study of korean adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203821/
https://www.ncbi.nlm.nih.gov/pubmed/30327562
http://dx.doi.org/10.1038/s41416-018-0214-7
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