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Multifunctional sequence-defined macromolecules for chemical data storage
Sequence-defined macromolecules consist of a defined chain length (single mass), end-groups, composition and topology and prove promising in application fields such as anti-counterfeiting, biological mimicking and data storage. Here we show the potential use of multifunctional sequence-defined macro...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203848/ https://www.ncbi.nlm.nih.gov/pubmed/30367037 http://dx.doi.org/10.1038/s41467-018-06926-3 |
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author | Martens, Steven Landuyt, Annelies Espeel, Pieter Devreese, Bart Dawyndt, Peter Du Prez, Filip |
author_facet | Martens, Steven Landuyt, Annelies Espeel, Pieter Devreese, Bart Dawyndt, Peter Du Prez, Filip |
author_sort | Martens, Steven |
collection | PubMed |
description | Sequence-defined macromolecules consist of a defined chain length (single mass), end-groups, composition and topology and prove promising in application fields such as anti-counterfeiting, biological mimicking and data storage. Here we show the potential use of multifunctional sequence-defined macromolecules as a storage medium. As a proof-of-principle, we describe how short text fragments (human-readable data) and QR codes (machine-readable data) are encoded as a collection of oligomers and how the original data can be reconstructed. The amide-urethane containing oligomers are generated using an automated protecting-group free, two-step iterative protocol based on thiolactone chemistry. Tandem mass spectrometry techniques have been explored to provide detailed analysis of the oligomer sequences. We have developed the generic software tools Chemcoder for encoding/decoding binary data as a collection of multifunctional macromolecules and Chemreader for reconstructing oligomer sequences from mass spectra to automate the process of chemical writing and reading. |
format | Online Article Text |
id | pubmed-6203848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-62038482018-10-29 Multifunctional sequence-defined macromolecules for chemical data storage Martens, Steven Landuyt, Annelies Espeel, Pieter Devreese, Bart Dawyndt, Peter Du Prez, Filip Nat Commun Article Sequence-defined macromolecules consist of a defined chain length (single mass), end-groups, composition and topology and prove promising in application fields such as anti-counterfeiting, biological mimicking and data storage. Here we show the potential use of multifunctional sequence-defined macromolecules as a storage medium. As a proof-of-principle, we describe how short text fragments (human-readable data) and QR codes (machine-readable data) are encoded as a collection of oligomers and how the original data can be reconstructed. The amide-urethane containing oligomers are generated using an automated protecting-group free, two-step iterative protocol based on thiolactone chemistry. Tandem mass spectrometry techniques have been explored to provide detailed analysis of the oligomer sequences. We have developed the generic software tools Chemcoder for encoding/decoding binary data as a collection of multifunctional macromolecules and Chemreader for reconstructing oligomer sequences from mass spectra to automate the process of chemical writing and reading. Nature Publishing Group UK 2018-10-26 /pmc/articles/PMC6203848/ /pubmed/30367037 http://dx.doi.org/10.1038/s41467-018-06926-3 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Martens, Steven Landuyt, Annelies Espeel, Pieter Devreese, Bart Dawyndt, Peter Du Prez, Filip Multifunctional sequence-defined macromolecules for chemical data storage |
title | Multifunctional sequence-defined macromolecules for chemical data storage |
title_full | Multifunctional sequence-defined macromolecules for chemical data storage |
title_fullStr | Multifunctional sequence-defined macromolecules for chemical data storage |
title_full_unstemmed | Multifunctional sequence-defined macromolecules for chemical data storage |
title_short | Multifunctional sequence-defined macromolecules for chemical data storage |
title_sort | multifunctional sequence-defined macromolecules for chemical data storage |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203848/ https://www.ncbi.nlm.nih.gov/pubmed/30367037 http://dx.doi.org/10.1038/s41467-018-06926-3 |
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