Phase 1 study of ARQ 761, a β-lapachone analogue that promotes NQO1-mediated programmed cancer cell necrosis

BACKGROUND: NAD(P)H:quinone oxidoreductase 1 (NQO1) is a two-electron oxidoreductase expressed in multiple tumour types. ARQ 761 is a β-lapachone (β-lap) analogue that exploits the unique elevation of NQO1 found in solid tumours to cause tumour-specific cell death. METHODS: We performed a 3+3 dose e...

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Detalles Bibliográficos
Autores principales: Gerber, David E., Beg, M. Shaalan, Fattah, Farjana, Frankel, Arthur E., Fatunde, Oluwatomilade, Arriaga, Yull, Dowell, Jonathan E., Bisen, Ajit, Leff, Richard D., Meek, Claudia C., Putnam, William C., Kallem, Raja Reddy, Subramaniyan, Indhumathy, Dong, Ying, Bolluyt, Joyce, Sarode, Venetia, Luo, Xin, Xie, Yang, Schwartz, Brian, Boothman, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203852/
https://www.ncbi.nlm.nih.gov/pubmed/30318513
http://dx.doi.org/10.1038/s41416-018-0278-4

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