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Construct validity and reliability of the Test Your Memory Chinese version in older neurology outpatient attendees
BACKGROUND: Early distinguishing the cognitive impairment from healthy population is crucial to delay the progression of mild cognitive impairment (MCI) and Alzheimer disease (AD). Test Your Memory (TYM) has been proved to be a valid and reliable screening instrument for AD and MCI. This study aimed...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203987/ https://www.ncbi.nlm.nih.gov/pubmed/30386423 http://dx.doi.org/10.1186/s13033-018-0240-0 |
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author | Li, Xuemei Zhang, Shengfa Zhang, Jinsui Zhu, Jingru He, Huan Zhang, Yurong Zhang, Weijun Tian, Donghua |
author_facet | Li, Xuemei Zhang, Shengfa Zhang, Jinsui Zhu, Jingru He, Huan Zhang, Yurong Zhang, Weijun Tian, Donghua |
author_sort | Li, Xuemei |
collection | PubMed |
description | BACKGROUND: Early distinguishing the cognitive impairment from healthy population is crucial to delay the progression of mild cognitive impairment (MCI) and Alzheimer disease (AD). Test Your Memory (TYM) has been proved to be a valid and reliable screening instrument for AD and MCI. This study aimed to develop a culturally appropriate and functional Standard Mandarin Chinese translation of the TYM, and to evaluate its reliability and validity in detecting AD and MCI in Chinese. METHODS: 182 subjects with AD/MCI and 55 healthy controls were recruited to participate in this study, and everyone undergo the test of Standard Mandarin Chinese version of the TYM (TYM-CN), Mini-mental State Examination (MMSE), Montreal cognitive assessment (MoCA-BJ), and Clinical Dementia Rating (CDR) Scale. Concurrently, all the subjects with AD/MCI received the general physical and neurologic examinations, extensive laboratory tests, and brain computed tomography/magnetic resonance imaging (MRI). Of which, 90 subjects were asked to complete the re-test of TYM-CN at 3 weeks after the initial visit. Intra-class correlation coefficient (ICC) and Cronbach’s alpha was used to assess the test–retest reliability and the internal consistency. The validity, sensitivity and specificity were also analyzed. One-way analysis of variance, χ(2) test, correlation analysis, and receiver operating characteristic curve (ROC) analysis were employed, as needed. RESULTS: The total scores of TYM-CN was 43.89 ± 3.44, 40.88 ± 4.38, and 29.12 ± 7.44 (p < 0.01) for healthy controls group, MCI group, and AD group, respectively. The ICC for 11 items of TYM-CN ranged from 0.863 (copying) to 0.994 (anterograde), and that of the total scale was 0.993, suggesting an excellent reliability. Furthermore, the significant correlation was also found between TYM-CN and MMSE (r = 0.76), MoCA-BJ (r = 0.74), and CDR scores (r = 0.76), indicating a good validity. A TYM-CN scores ≤ 39.5 had 95% sensitivity and 95% specificity in differentiating AD from healthy controls, and that ≤ 43.5 had 75% sensitivity and 91% specificity in distinguishing MCI from healthy controls, respectively. CONCLUSION: The reliability and validity of the TYM-CN are statistically acceptable for the evaluation of cognitive impairment, which may contribute to neuropsychological tests for the diagnosis of AD and MCI from healthy controls in China. |
format | Online Article Text |
id | pubmed-6203987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-62039872018-11-01 Construct validity and reliability of the Test Your Memory Chinese version in older neurology outpatient attendees Li, Xuemei Zhang, Shengfa Zhang, Jinsui Zhu, Jingru He, Huan Zhang, Yurong Zhang, Weijun Tian, Donghua Int J Ment Health Syst Research BACKGROUND: Early distinguishing the cognitive impairment from healthy population is crucial to delay the progression of mild cognitive impairment (MCI) and Alzheimer disease (AD). Test Your Memory (TYM) has been proved to be a valid and reliable screening instrument for AD and MCI. This study aimed to develop a culturally appropriate and functional Standard Mandarin Chinese translation of the TYM, and to evaluate its reliability and validity in detecting AD and MCI in Chinese. METHODS: 182 subjects with AD/MCI and 55 healthy controls were recruited to participate in this study, and everyone undergo the test of Standard Mandarin Chinese version of the TYM (TYM-CN), Mini-mental State Examination (MMSE), Montreal cognitive assessment (MoCA-BJ), and Clinical Dementia Rating (CDR) Scale. Concurrently, all the subjects with AD/MCI received the general physical and neurologic examinations, extensive laboratory tests, and brain computed tomography/magnetic resonance imaging (MRI). Of which, 90 subjects were asked to complete the re-test of TYM-CN at 3 weeks after the initial visit. Intra-class correlation coefficient (ICC) and Cronbach’s alpha was used to assess the test–retest reliability and the internal consistency. The validity, sensitivity and specificity were also analyzed. One-way analysis of variance, χ(2) test, correlation analysis, and receiver operating characteristic curve (ROC) analysis were employed, as needed. RESULTS: The total scores of TYM-CN was 43.89 ± 3.44, 40.88 ± 4.38, and 29.12 ± 7.44 (p < 0.01) for healthy controls group, MCI group, and AD group, respectively. The ICC for 11 items of TYM-CN ranged from 0.863 (copying) to 0.994 (anterograde), and that of the total scale was 0.993, suggesting an excellent reliability. Furthermore, the significant correlation was also found between TYM-CN and MMSE (r = 0.76), MoCA-BJ (r = 0.74), and CDR scores (r = 0.76), indicating a good validity. A TYM-CN scores ≤ 39.5 had 95% sensitivity and 95% specificity in differentiating AD from healthy controls, and that ≤ 43.5 had 75% sensitivity and 91% specificity in distinguishing MCI from healthy controls, respectively. CONCLUSION: The reliability and validity of the TYM-CN are statistically acceptable for the evaluation of cognitive impairment, which may contribute to neuropsychological tests for the diagnosis of AD and MCI from healthy controls in China. BioMed Central 2018-10-26 /pmc/articles/PMC6203987/ /pubmed/30386423 http://dx.doi.org/10.1186/s13033-018-0240-0 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Li, Xuemei Zhang, Shengfa Zhang, Jinsui Zhu, Jingru He, Huan Zhang, Yurong Zhang, Weijun Tian, Donghua Construct validity and reliability of the Test Your Memory Chinese version in older neurology outpatient attendees |
title | Construct validity and reliability of the Test Your Memory Chinese version in older neurology outpatient attendees |
title_full | Construct validity and reliability of the Test Your Memory Chinese version in older neurology outpatient attendees |
title_fullStr | Construct validity and reliability of the Test Your Memory Chinese version in older neurology outpatient attendees |
title_full_unstemmed | Construct validity and reliability of the Test Your Memory Chinese version in older neurology outpatient attendees |
title_short | Construct validity and reliability of the Test Your Memory Chinese version in older neurology outpatient attendees |
title_sort | construct validity and reliability of the test your memory chinese version in older neurology outpatient attendees |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203987/ https://www.ncbi.nlm.nih.gov/pubmed/30386423 http://dx.doi.org/10.1186/s13033-018-0240-0 |
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