Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4

BACKGROUND: Evidence indicates a cross-regulation between two kinases, leucine-rich repeat kinase 2 (LRRK2) and protein kinase A (PKA). In neurons, LRRK2 negatively regulates PKA activity in spiny projecting neurons during synaptogenesis and in response to dopamine D1 receptor activation acting as a...

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Detalles Bibliográficos
Autores principales: Russo, Isabella, Di Benedetto, Giulietta, Kaganovich, Alice, Ding, Jinhui, Mercatelli, Daniela, Morari, Michele, Cookson, Mark R., Bubacco, Luigi, Greggio, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204045/
https://www.ncbi.nlm.nih.gov/pubmed/30368241
http://dx.doi.org/10.1186/s12974-018-1337-8

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