Critical Period Inhibition of NKCC1 Rectifies Synapse Plasticity in the Somatosensory cortex and Restores Adult Tactile Response Maps in Fragile X Mice

Sensory perturbations in visual, auditory and tactile perception are core problems in Fragile X Syndrome (FXS). In the Fmr1 knockout mouse model of FXS, the maturation of synapses and circuits during critical period (CP) development in the somatosensory cortex is delayed, but it is unclear how this...

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Detalles Bibliográficos
Autores principales: He, Qionger, Arroyo, Erica D, Smukowski, Samuel N, Xu, Jian, Piochon, Claire, Savas, Jeffrey N, Portera-Cailliau, Carlos, Contractor, Anis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204122/
https://www.ncbi.nlm.nih.gov/pubmed/29703945
http://dx.doi.org/10.1038/s41380-018-0048-y

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