Cargando…

CRISPR/Cas9 can mediate high-efficiency off-target mutations in mice in vivo

Detalles Bibliográficos
Autores principales:	Aryal, Neeraj K, Wasylishen, Amanda R, Lozano, Guillermina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Comment
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204134/ https://www.ncbi.nlm.nih.gov/pubmed/30368519 http://dx.doi.org/10.1038/s41419-018-1146-0

Ejemplares similares

Cas9 immunity creates challenges for CRISPR gene editing therapies
por: Crudele, Julie M., et al.
Publicado: (2018)

Loss of digestive organ expansion factor (Diexf) reveals an essential role during murine embryonic development that is independent of p53
por: Aryal, Neeraj K., et al.
Publicado: (2017)

Pathogen detection in the CRISPR–Cas era
por: Sashital, Dipali G.
Publicado: (2018)

Knocking out consumer concerns and regulator’s rules: efficient use of CRISPR/Cas ribonucleoprotein complexes for genome editing in cereals
por: Wolter, Felix, et al.
Publicado: (2017)

Mitigating off-target effects in CRISPR/Cas9-mediated in vivo gene editing
por: Han, Hua Alexander, et al.
Publicado: (2020)

Rescue of an aggressive female sexual courtship in mice by CRISPR/Cas9 secondary mutation in vivo
por: Zakany, Jozsef, et al.
Publicado: (2018)

Multigene Knockout Utilizing Off-Target Mutations of the CRISPR/Cas9 System in Rice
por: Endo, Masaki, et al.
Publicado: (2015)

Genetic variation may confound analysis of CRISPR-Cas9 off-target mutations
por: Wang, Guanqun, et al.
Publicado: (2018)

Efficient Generation of Myostatin Gene Mutated Rabbit by CRISPR/Cas9
por: Lv, Qingyan, et al.
Publicado: (2016)

Genome-Wide Off-Target Analysis in CRISPR-Cas9 Modified Mice and Their Offspring
por: Dong, Yan, et al.
Publicado: (2019)

CRISPRon/off: CRISPR/Cas9 on- and off-target gRNA design
por: Anthon, Christian, et al.
Publicado: (2022)

Off-target effects in CRISPR/Cas9 gene editing
por: Guo, Congting, et al.
Publicado: (2023)

Efficient In Vivo Liver-Directed Gene Editing Using CRISPR/Cas9
por: Singh, Kshitiz, et al.
Publicado: (2018)

In vivo Analysis of CRISPR/Cas9 Induced Atlastin Pathological Mutations in Drosophila
por: Montagna, Aldo, et al.
Publicado: (2020)

Efficient Generation of Myostatin Mutations in Pigs Using the CRISPR/Cas9 System
por: Wang, Kankan, et al.
Publicado: (2015)

Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo
por: Wasylishen, Amanda R., et al.
Publicado: (2020)

Off-target Effects in CRISPR/Cas9-mediated Genome Engineering
por: Zhang, Xiao-Hui, et al.
Publicado: (2015)

Whole-genome sequencing reveals rare off-target mutations in CRISPR/Cas9-edited grapevine
por: Wang, Xianhang, et al.
Publicado: (2021)

CRISPRscan: designing highly efficient sgRNAs for CRISPR/Cas9 targeting in vivo
por: Moreno-Mateos, Miguel A., et al.
Publicado: (2015)

No unexpected CRISPR-Cas9 off-target activity revealed by trio sequencing of gene-edited mice
por: Iyer, Vivek, et al.
Publicado: (2018)

Inducible in vivo genome editing with CRISPR/Cas9
por: Dow, Lukas E, et al.
Publicado: (2015)

Highly efficient neuronal gene knockout in vivo by CRISPR-Cas9 via neonatal intracerebroventricular injection of AAV in mice
por: Hana, Sam, et al.
Publicado: (2021)

Increased mutation efficiency of CRISPR/Cas9 genome editing in banana by optimized construct
por: Zhang, Sen, et al.
Publicado: (2022)

Efficient Mitochondrial Genome Editing by CRISPR/Cas9
por: Jo, Areum, et al.
Publicado: (2015)

Evaluation of the CRISPR/Cas9 Genetic Constructs in Efficient Disruption of Porcine Genes for Xenotransplantation Purposes Along with an Assessment of the Off-Target Mutation Formation
por: Ryczek, Natalia, et al.
Publicado: (2020)

Turning Up the Temperature on CRISPR: Increased Temperature Can Improve the Editing Efficiency of Wheat Using CRISPR/Cas9
por: Milner, Matthew J., et al.
Publicado: (2020)

Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease
por: Qin, Wenning, et al.
Publicado: (2015)

FrCas9 is a CRISPR/Cas9 system with high editing efficiency and fidelity
por: Cui, Zifeng, et al.
Publicado: (2022)

Effective use of sequence information to predict CRISPR-Cas9 off-target
por: Zhang, Zhong-Rui, et al.
Publicado: (2022)

Evaluation of Homology-Independent CRISPR-Cas9 Off-Target Assessment Methods
por: Chaudhari, Hemangi G., et al.
Publicado: (2020)

CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations
por: Höijer, Ida, et al.
Publicado: (2022)

Efficient correction of a deleterious point mutation in primary horse fibroblasts with CRISPR-Cas9
por: Pinzon-Arteaga, Carlos, et al.
Publicado: (2020)

Efficient Method for Generating Point Mutations in the Vaccinia Virus Genome Using CRISPR/Cas9
por: Boutin, Laetitia, et al.
Publicado: (2022)

Whole genome analysis of CRISPR Cas9 sgRNA off-target homologies via an efficient computational algorithm
por: Zhou, Hong, et al.
Publicado: (2017)

CRISPR-Cas9 for in vivo Gene Therapy: Promise and Hurdles
por: Dai, Wei-Jing, et al.
Publicado: (2016)

Nucleosomes inhibit target cleavage by CRISPR-Cas9 in vivo
por: Yarrington, Robert M., et al.
Publicado: (2018)

In vivo delivery of CRISPR-Cas9 therapeutics: Progress and challenges
por: Behr, Matthew, et al.
Publicado: (2021)

CRISPR/Cas9 Mediates Efficient Conditional Mutagenesis in Drosophila
por: Xue, Zhaoyu, et al.
Publicado: (2014)

Efficient genome editing with CRISPR/Cas9 in Pleurotus ostreatus
por: Boontawon, Tatpong, et al.
Publicado: (2021)

piCRISPR: Physically informed deep learning models for CRISPR/Cas9 off-target cleavage prediction
por: Störtz, Florian, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_dpq5225m4hr9d6e5hc4ljrranm