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A new synthetic derivative of cryptotanshinone KYZ3 as STAT3 inhibitor for triple-negative breast cancer therapy

Silencing STAT3 is confirmed as a promising therapeutic strategy for triple-negative breast cancer (TNBC) therapy to address the issue of its poor prognosis. In this study, the natural product cryptotanshinone was firstly remodeled and modified as a more effective STAT3 inhibitor by structure-based...

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Detalles Bibliográficos
Autores principales:	Zhang, Wenda, Yu, Wenying, Cai, Guiping, Zhu, Jiawen, Zhang, Chao, Li, Shanshan, Guo, Jianpeng, Yin, Guoping, Chen, Chen, Kong, Lingyi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204138/ https://www.ncbi.nlm.nih.gov/pubmed/30368518 http://dx.doi.org/10.1038/s41419-018-1139-z

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