Cargando…
Probiotics and their role in gastrointestinal cancers prevention and treatment; an overview
Cancers of the gastrointestinal (GI) track are a serious global health problem. The human GI tract is home to trillions of microorganisms that known as gut microbiota and have established a symbiotic relationship with the host. The human intestinal microbiota plays an important role in the developme...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shaheed Beheshti University of Medical Sciences
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204245/ https://www.ncbi.nlm.nih.gov/pubmed/30425806 |
_version_ | 1783366012376186880 |
---|---|
author | Javanmard, Ahmad Ashtari, Sara Sabet, Babak Davoodi, Seyed Hossein Rostami-Nejad, Mohammad Esmaeil Akbari, Mohammad Niaz, Azadeh Mortazavian, Amir Mohammad |
author_facet | Javanmard, Ahmad Ashtari, Sara Sabet, Babak Davoodi, Seyed Hossein Rostami-Nejad, Mohammad Esmaeil Akbari, Mohammad Niaz, Azadeh Mortazavian, Amir Mohammad |
author_sort | Javanmard, Ahmad |
collection | PubMed |
description | Cancers of the gastrointestinal (GI) track are a serious global health problem. The human GI tract is home to trillions of microorganisms that known as gut microbiota and have established a symbiotic relationship with the host. The human intestinal microbiota plays an important role in the development of the gut immune system, metabolism, nutrition absorption, production of short-chain fatty acids and essential vitamins, resistance to pathogenic microorganisms, and modulates a normal immunological response. Microbiota imbalance has been involved in many disorders including inflammatory bowel disease, obesity, asthma, psychiatric illnesses, and cancers. Oral administration of probiotics seems to play a protective role against cancer development as a kind of functional foods. Moreover, clinical application of probiotics has shown that some probiotic strains can reduce the incidence of post-operative inflammation in cancer patients. In the present narrative review, we carried out update knowledge on probiotic effects and underlying mechanism to GI cancers. Currently, it is accept that most commercial probiotic products are generally safe and can used as a supplement for cancer prevention and treatment. Nevertheless, well-designed, randomized, double blind, placebo-controlled human studies are required to gain the acceptance of the potential probiotics as an alternative therapy for cancer control.. |
format | Online Article Text |
id | pubmed-6204245 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Shaheed Beheshti University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-62042452018-11-13 Probiotics and their role in gastrointestinal cancers prevention and treatment; an overview Javanmard, Ahmad Ashtari, Sara Sabet, Babak Davoodi, Seyed Hossein Rostami-Nejad, Mohammad Esmaeil Akbari, Mohammad Niaz, Azadeh Mortazavian, Amir Mohammad Gastroenterol Hepatol Bed Bench Review Article Cancers of the gastrointestinal (GI) track are a serious global health problem. The human GI tract is home to trillions of microorganisms that known as gut microbiota and have established a symbiotic relationship with the host. The human intestinal microbiota plays an important role in the development of the gut immune system, metabolism, nutrition absorption, production of short-chain fatty acids and essential vitamins, resistance to pathogenic microorganisms, and modulates a normal immunological response. Microbiota imbalance has been involved in many disorders including inflammatory bowel disease, obesity, asthma, psychiatric illnesses, and cancers. Oral administration of probiotics seems to play a protective role against cancer development as a kind of functional foods. Moreover, clinical application of probiotics has shown that some probiotic strains can reduce the incidence of post-operative inflammation in cancer patients. In the present narrative review, we carried out update knowledge on probiotic effects and underlying mechanism to GI cancers. Currently, it is accept that most commercial probiotic products are generally safe and can used as a supplement for cancer prevention and treatment. Nevertheless, well-designed, randomized, double blind, placebo-controlled human studies are required to gain the acceptance of the potential probiotics as an alternative therapy for cancer control.. Shaheed Beheshti University of Medical Sciences 2018 /pmc/articles/PMC6204245/ /pubmed/30425806 Text en ©2018 RIGLD, Research Institute for Gastroenterology and Liver Diseases This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Javanmard, Ahmad Ashtari, Sara Sabet, Babak Davoodi, Seyed Hossein Rostami-Nejad, Mohammad Esmaeil Akbari, Mohammad Niaz, Azadeh Mortazavian, Amir Mohammad Probiotics and their role in gastrointestinal cancers prevention and treatment; an overview |
title | Probiotics and their role in gastrointestinal cancers prevention and treatment; an overview |
title_full | Probiotics and their role in gastrointestinal cancers prevention and treatment; an overview |
title_fullStr | Probiotics and their role in gastrointestinal cancers prevention and treatment; an overview |
title_full_unstemmed | Probiotics and their role in gastrointestinal cancers prevention and treatment; an overview |
title_short | Probiotics and their role in gastrointestinal cancers prevention and treatment; an overview |
title_sort | probiotics and their role in gastrointestinal cancers prevention and treatment; an overview |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204245/ https://www.ncbi.nlm.nih.gov/pubmed/30425806 |
work_keys_str_mv | AT javanmardahmad probioticsandtheirroleingastrointestinalcancerspreventionandtreatmentanoverview AT ashtarisara probioticsandtheirroleingastrointestinalcancerspreventionandtreatmentanoverview AT sabetbabak probioticsandtheirroleingastrointestinalcancerspreventionandtreatmentanoverview AT davoodiseyedhossein probioticsandtheirroleingastrointestinalcancerspreventionandtreatmentanoverview AT rostaminejadmohammad probioticsandtheirroleingastrointestinalcancerspreventionandtreatmentanoverview AT esmaeilakbarimohammad probioticsandtheirroleingastrointestinalcancerspreventionandtreatmentanoverview AT niazazadeh probioticsandtheirroleingastrointestinalcancerspreventionandtreatmentanoverview AT mortazavianamirmohammad probioticsandtheirroleingastrointestinalcancerspreventionandtreatmentanoverview |