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The impact of exercise training and resveratrol supplementation on gut microbiota composition in high‐fat diet fed mice

The aim of this study was to examine the effect of exercise training and dietary supplementation of resveratrol on the composition of gut microbiota and to test the hypothesis that exercise training and resveratrol can prevent high‐fat diet (HFD)‐induced changes in the gut microbiota. Mice fed a HFD...

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Autores principales: Brandt, Nina, Kotowska, Dorota, Kristensen, Caroline M., Olesen, Jesper, Lützhøft, Ditte O., Halling, Jens F., Hansen, Martin, Al‐Soud, Waleed A., Hansen, Lars, Kiilerich, Pia, Pilegaard, Henriette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204360/
https://www.ncbi.nlm.nih.gov/pubmed/30370643
http://dx.doi.org/10.14814/phy2.13881
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author Brandt, Nina
Kotowska, Dorota
Kristensen, Caroline M.
Olesen, Jesper
Lützhøft, Ditte O.
Halling, Jens F.
Hansen, Martin
Al‐Soud, Waleed A.
Hansen, Lars
Kiilerich, Pia
Pilegaard, Henriette
author_facet Brandt, Nina
Kotowska, Dorota
Kristensen, Caroline M.
Olesen, Jesper
Lützhøft, Ditte O.
Halling, Jens F.
Hansen, Martin
Al‐Soud, Waleed A.
Hansen, Lars
Kiilerich, Pia
Pilegaard, Henriette
author_sort Brandt, Nina
collection PubMed
description The aim of this study was to examine the effect of exercise training and dietary supplementation of resveratrol on the composition of gut microbiota and to test the hypothesis that exercise training and resveratrol can prevent high‐fat diet (HFD)‐induced changes in the gut microbiota. Mice fed a HFD supplemented with resveratrol (4 g/kg food) were protected against diet‐induced obesity, while exercise trained HFD‐fed animals (running on average 50 km/week) were not. Dietary resveratrol supplementation induced changes predominantly in the low‐abundant bacteria, while exercise training induced changes in the high‐abundant bacteria in the gut as analyzed by ADONIS test with Weighted UniFrac distances. Interestingly, the two interventions affected the gut microbiome independently of the inflammatory state of the HFD‐fed animals as assessed by the systemic serum amyloid A levels. These results suggest that both resveratrol supplementation and regular physical activity modulate the composition of murine microbiota independently of the systemic inflammatory state. Moreover, the effects of exercise training on the microbiota seem to occur without changes in adiposity, while resveratrol‐mediated alterations may relate to adipose tissue mass.
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spelling pubmed-62043602018-11-05 The impact of exercise training and resveratrol supplementation on gut microbiota composition in high‐fat diet fed mice Brandt, Nina Kotowska, Dorota Kristensen, Caroline M. Olesen, Jesper Lützhøft, Ditte O. Halling, Jens F. Hansen, Martin Al‐Soud, Waleed A. Hansen, Lars Kiilerich, Pia Pilegaard, Henriette Physiol Rep Original Research The aim of this study was to examine the effect of exercise training and dietary supplementation of resveratrol on the composition of gut microbiota and to test the hypothesis that exercise training and resveratrol can prevent high‐fat diet (HFD)‐induced changes in the gut microbiota. Mice fed a HFD supplemented with resveratrol (4 g/kg food) were protected against diet‐induced obesity, while exercise trained HFD‐fed animals (running on average 50 km/week) were not. Dietary resveratrol supplementation induced changes predominantly in the low‐abundant bacteria, while exercise training induced changes in the high‐abundant bacteria in the gut as analyzed by ADONIS test with Weighted UniFrac distances. Interestingly, the two interventions affected the gut microbiome independently of the inflammatory state of the HFD‐fed animals as assessed by the systemic serum amyloid A levels. These results suggest that both resveratrol supplementation and regular physical activity modulate the composition of murine microbiota independently of the systemic inflammatory state. Moreover, the effects of exercise training on the microbiota seem to occur without changes in adiposity, while resveratrol‐mediated alterations may relate to adipose tissue mass. John Wiley and Sons Inc. 2018-10-28 /pmc/articles/PMC6204360/ /pubmed/30370643 http://dx.doi.org/10.14814/phy2.13881 Text en © 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Brandt, Nina
Kotowska, Dorota
Kristensen, Caroline M.
Olesen, Jesper
Lützhøft, Ditte O.
Halling, Jens F.
Hansen, Martin
Al‐Soud, Waleed A.
Hansen, Lars
Kiilerich, Pia
Pilegaard, Henriette
The impact of exercise training and resveratrol supplementation on gut microbiota composition in high‐fat diet fed mice
title The impact of exercise training and resveratrol supplementation on gut microbiota composition in high‐fat diet fed mice
title_full The impact of exercise training and resveratrol supplementation on gut microbiota composition in high‐fat diet fed mice
title_fullStr The impact of exercise training and resveratrol supplementation on gut microbiota composition in high‐fat diet fed mice
title_full_unstemmed The impact of exercise training and resveratrol supplementation on gut microbiota composition in high‐fat diet fed mice
title_short The impact of exercise training and resveratrol supplementation on gut microbiota composition in high‐fat diet fed mice
title_sort impact of exercise training and resveratrol supplementation on gut microbiota composition in high‐fat diet fed mice
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204360/
https://www.ncbi.nlm.nih.gov/pubmed/30370643
http://dx.doi.org/10.14814/phy2.13881
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