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In Vivo Selectivity and Localization of Reactive Oxygen Species (ROS) Induction by Osmium Anticancer Complexes That Circumvent Platinum Resistance

[Image: see text] Platinum drugs are widely used for cancer treatment. Other precious metals are promising, but their clinical progress depends on achieving different mechanisms of action to overcome Pt-resistance. Here, we evaluate 13 organo-Os complexes: 16-electron sulfonyl-diamine catalysts [(η(...

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Detalles Bibliográficos
Autores principales:	Coverdale, James P. C., Bridgewater, Hannah E., Song, Ji-Inn, Smith, Nichola A., Barry, Nicolas P. E., Bagley, Ian, Sadler, Peter J., Romero-Canelón, Isolda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204601/ https://www.ncbi.nlm.nih.gov/pubmed/30230827 http://dx.doi.org/10.1021/acs.jmedchem.8b00958

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