Therapeutic Potential of small Activating RNAs (saRNAs) in Human Cancers

BACKGROUND: RNA is increasingly recognized as a powerful molecule that can be used to control gene expression. Sophisticated, well-engineered RNA-based regulators are being developed as oligotherapeutics. METHODS: In particular, small activating RNAs (saRNAs) are promising therapeutic options for ta...

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Detalles Bibliográficos
Autores principales: Yoon, Sorah, Rossi, John J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204660/
https://www.ncbi.nlm.nih.gov/pubmed/29804529
http://dx.doi.org/10.2174/1389201019666180528084059
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author Yoon, Sorah
Rossi, John J.
author_facet Yoon, Sorah
Rossi, John J.
author_sort Yoon, Sorah
collection PubMed
description BACKGROUND: RNA is increasingly recognized as a powerful molecule that can be used to control gene expression. Sophisticated, well-engineered RNA-based regulators are being developed as oligotherapeutics. METHODS: In particular, small activating RNAs (saRNAs) are promising therapeutic options for targeting human diseases. Numerous saRNAs targeting multiple cancers have been developed in preclinical models. One saRNA targeting C/EBPα is currently undergoing clinical trials in liver cancer. Results and CONCLUSION: In this review, we describe the current working model of the intracellular mechanism of saRNA, discuss the recent progress of saRNA therapeutics in preclinical and clinical trials, and current advances in targeted delivery using aptamers in detail.
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spelling pubmed-62046602018-11-16 Therapeutic Potential of small Activating RNAs (saRNAs) in Human Cancers Yoon, Sorah Rossi, John J. Curr Pharm Biotechnol Article BACKGROUND: RNA is increasingly recognized as a powerful molecule that can be used to control gene expression. Sophisticated, well-engineered RNA-based regulators are being developed as oligotherapeutics. METHODS: In particular, small activating RNAs (saRNAs) are promising therapeutic options for targeting human diseases. Numerous saRNAs targeting multiple cancers have been developed in preclinical models. One saRNA targeting C/EBPα is currently undergoing clinical trials in liver cancer. Results and CONCLUSION: In this review, we describe the current working model of the intracellular mechanism of saRNA, discuss the recent progress of saRNA therapeutics in preclinical and clinical trials, and current advances in targeted delivery using aptamers in detail. Bentham Science Publishers 2018-07 2018-07 /pmc/articles/PMC6204660/ /pubmed/29804529 http://dx.doi.org/10.2174/1389201019666180528084059 Text en © 2018 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Yoon, Sorah
Rossi, John J.
Therapeutic Potential of small Activating RNAs (saRNAs) in Human Cancers
title Therapeutic Potential of small Activating RNAs (saRNAs) in Human Cancers
title_full Therapeutic Potential of small Activating RNAs (saRNAs) in Human Cancers
title_fullStr Therapeutic Potential of small Activating RNAs (saRNAs) in Human Cancers
title_full_unstemmed Therapeutic Potential of small Activating RNAs (saRNAs) in Human Cancers
title_short Therapeutic Potential of small Activating RNAs (saRNAs) in Human Cancers
title_sort therapeutic potential of small activating rnas (sarnas) in human cancers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204660/
https://www.ncbi.nlm.nih.gov/pubmed/29804529
http://dx.doi.org/10.2174/1389201019666180528084059
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