Cargando…
Synthesis of functionalised β-keto amides by aminoacylation/domino fragmentation of β-enamino amides
Ethylenediamine-derived β-enamino amides are used as equivalents of amide enolate synthons in C-acylation reactions with N-protected amino acids. Domino fragmentation of the obtained intermediates leads to functionalised β-keto amides, bearing a protected amino group in their side chain.
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204755/ https://www.ncbi.nlm.nih.gov/pubmed/30410622 http://dx.doi.org/10.3762/bjoc.14.238 |
| _version_ | 1783366085368610816 |
|---|---|
| author | Yanev, Pavel Angelov, Plamen |
| author_facet | Yanev, Pavel Angelov, Plamen |
| author_sort | Yanev, Pavel |
| collection | PubMed |
| description | Ethylenediamine-derived β-enamino amides are used as equivalents of amide enolate synthons in C-acylation reactions with N-protected amino acids. Domino fragmentation of the obtained intermediates leads to functionalised β-keto amides, bearing a protected amino group in their side chain. |
| format | Online Article Text |
| id | pubmed-6204755 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Beilstein-Institut |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-62047552018-11-08 Synthesis of functionalised β-keto amides by aminoacylation/domino fragmentation of β-enamino amides Yanev, Pavel Angelov, Plamen Beilstein J Org Chem Full Research Paper Ethylenediamine-derived β-enamino amides are used as equivalents of amide enolate synthons in C-acylation reactions with N-protected amino acids. Domino fragmentation of the obtained intermediates leads to functionalised β-keto amides, bearing a protected amino group in their side chain. Beilstein-Institut 2018-10-10 /pmc/articles/PMC6204755/ /pubmed/30410622 http://dx.doi.org/10.3762/bjoc.14.238 Text en Copyright © 2018, Yanev and Angelov https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms) |
| spellingShingle | Full Research Paper Yanev, Pavel Angelov, Plamen Synthesis of functionalised β-keto amides by aminoacylation/domino fragmentation of β-enamino amides |
| title | Synthesis of functionalised β-keto amides by aminoacylation/domino fragmentation of β-enamino amides |
| title_full | Synthesis of functionalised β-keto amides by aminoacylation/domino fragmentation of β-enamino amides |
| title_fullStr | Synthesis of functionalised β-keto amides by aminoacylation/domino fragmentation of β-enamino amides |
| title_full_unstemmed | Synthesis of functionalised β-keto amides by aminoacylation/domino fragmentation of β-enamino amides |
| title_short | Synthesis of functionalised β-keto amides by aminoacylation/domino fragmentation of β-enamino amides |
| title_sort | synthesis of functionalised β-keto amides by aminoacylation/domino fragmentation of β-enamino amides |
| topic | Full Research Paper |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204755/ https://www.ncbi.nlm.nih.gov/pubmed/30410622 http://dx.doi.org/10.3762/bjoc.14.238 |
| work_keys_str_mv | AT yanevpavel synthesisoffunctionalisedbketoamidesbyaminoacylationdominofragmentationofbenaminoamides AT angelovplamen synthesisoffunctionalisedbketoamidesbyaminoacylationdominofragmentationofbenaminoamides |