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Using Quantitative Systems Toxicology to Investigate Observed Species Differences in CKA-Mediated Hepatotoxicity

CKA, a chemokine receptor antagonist intended for treating inflammatory conditions, produced dose-dependent hepatotoxicity in rats but advanced into the clinic where single doses of CKA up to 600 mg appeared safe in humans. Because existing toxicological platforms used during drug development are no...

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Detalles Bibliográficos
Autores principales:	Battista, Christina, Yang, Kyunghee, Stahl, Simone H, Mettetal, Jerome T, Watkins, Paul B, Siler, Scott Q, Howell, Brett A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Systems Toxicology and Cka-Mediated Hepatotoxicity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204762/ https://www.ncbi.nlm.nih.gov/pubmed/30060248 http://dx.doi.org/10.1093/toxsci/kfy191

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