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Multi-angle light scattering as a process analytical technology measuring real-time molecular weight for downstream process control

For many protein therapeutics including monoclonal antibodies, aggregate removal process can be complex and challenging. We evaluated two different process analytical technology (PAT) applications that couple a purification unit performing preparative hydrophobic interaction chromatography (HIC) to...

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Detalles Bibliográficos
Autores principales:	Patel, Bhumit A., Gospodarek, Adrian, Larkin, Michael, Kenrick, Sophia A., Haverick, Mark A., Tugcu, Nihal, Brower, Mark A., Richardson, Douglas D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2018
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204791/ https://www.ncbi.nlm.nih.gov/pubmed/30130442 http://dx.doi.org/10.1080/19420862.2018.1505178

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