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High-throughput screening of antibody variants for chemical stability: identification of deamidation-resistant mutants

Developability assessment of therapeutic antibody candidates assists drug discovery by enabling early identification of undesirable instabilities. Rapid chemical stability screening of antibody variants can accelerate the identification of potential solutions. We describe here the development of a h...

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Detalles Bibliográficos
Autores principales:	DiCara, Danielle M., Andersen, Nisana, Chan, Ruby, Ernst, James A., Ayalon, Gai, Lazar, Greg A., Agard, Nicholas J., Hilderbrand, Amy, Hötzel, Isidro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2018
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204805/ https://www.ncbi.nlm.nih.gov/pubmed/30130444 http://dx.doi.org/10.1080/19420862.2018.1504726

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