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Synthesis of 3-aminocoumarin-N-benzylpyridinium conjugates with nanomolar inhibitory activity against acetylcholinesterase

A series of 3-amino-6,7-dimethoxycoumarins conjugated with the N-benzylpyridinium moiety through an amide-bond linkage was synthesized and evaluated for their acetylcholinesterase inhibitory activity. A number of the benzylpyridinium derivatives exhibited potent activities with inhibitory concentrat...

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Detalles Bibliográficos
Autores principales:	Khunnawutmanotham, Nisachon, Laongthipparos, Cherdchai, Saparpakorn, Patchreenart, Chimnoi, Nitirat, Techasakul, Supanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2018
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204823/ https://www.ncbi.nlm.nih.gov/pubmed/30410615 http://dx.doi.org/10.3762/bjoc.14.231

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