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Microwave-assisted synthesis of biologically relevant steroidal 17-exo-pyrazol-5'-ones from a norpregnene precursor by a side-chain elongation/heterocyclization sequence

Multistep syntheses of novel 17β-pyrazol-5'-ones in the Δ(5)-androstane series were efficiently carried out from pregnenolone acetate. A steroidal 17-carboxylic acid was first synthesized as a norpregnene precursor by the bromoform reaction and subsequent acetylation. Its CDI-activated acylimid...

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Detalles Bibliográficos
Autores principales:	Mótyán, Gergő, Mérai, László, Kiss, Márton Attila, Schelz, Zsuzsanna, Sinka, Izabella, Zupkó, István, Frank, Éva
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2018
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204839/ https://www.ncbi.nlm.nih.gov/pubmed/30410620 http://dx.doi.org/10.3762/bjoc.14.236

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