Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury

BACKGROUND: Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2. In the setting of acute injury, selective inhibition of TNFR1 is predicted to attenua...

Descripción completa

Detalles Bibliográficos
Autores principales: Proudfoot, Alastair, Bayliffe, Andrew, O’Kane, Cecilia M, Wright, Tracey, Serone, Adrian, Bareille, Philippe Jean, Brown, Vanessa, Hamid, Umar I, Chen, Younan, Wilson, Robert, Cordy, Joanna, Morley, Peter, de Wildt, Ruud, Elborn, Stuart, Hind, Matthew, Chilvers, Edwin R, Griffiths, Mark, Summers, Charlotte, McAuley, Daniel Francis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Critical Care
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204954/
https://www.ncbi.nlm.nih.gov/pubmed/29382797
http://dx.doi.org/10.1136/thoraxjnl-2017-210305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204954/
https://www.ncbi.nlm.nih.gov/pubmed/29382797
http://dx.doi.org/10.1136/thoraxjnl-2017-210305

Ejemplares similares