Whole cell melanoma vaccine genetically modified to stem cells like phenotype generates specific immune responses to ALDH1A1 and long-term survival in advanced melanoma patients

Allogeneic whole cell gene modified therapeutic melanoma vaccine (AGI-101H) comprising of two melanoma cell lines transduced with cDNA encoding fusion protein composed of IL-6 linked with the soluble IL-6 receptor (sIL-6R), referred to as H6 was developed. H6 served as a molecular adjuvant, however,...

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Detalles Bibliográficos
Autores principales: Kwiatkowska-Borowczyk, Eliza, Czerwińska, Patrycja, Mackiewicz, Jacek, Gryska, Katarzyna, Kazimierczak, Urszula, Tomela, Katarzyna, Przybyła, Anna, Kozłowska, Anna Karolina, Galus, Łukasz, Kwinta, Łukasz, Dondajewska, Ewelina, Gąbka-Buszek, Agnieszka, Żakowska, Monika, Mackiewicz, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205007/
https://www.ncbi.nlm.nih.gov/pubmed/30377573
http://dx.doi.org/10.1080/2162402X.2018.1509821

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