Evaluation of the use of tranexamic acid in total knee arthroplasty()

OBJECTIVE: Evaluate the efficacy of tranexamic acid in reducing bleeding in patients undergoing total knee arthroplasty. METHODS: 101 patients were randomized into two groups: the tranexamic acid group (n = 51) and the placebo group (n = 50). Patients were compared regarding the following parameters...

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Detalles Bibliográficos
Autores principales: Almeida, Mariana Diana Chaves de, Albuquerque, Rodrigo Pires e, Palhares, Guilherme Mathias, Almeida, Juliana Patrícia Chaves de, Barretto, João Mauricio, Cavanellas, Naasson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205013/
https://www.ncbi.nlm.nih.gov/pubmed/30377612
http://dx.doi.org/10.1016/j.rboe.2018.09.008
Descripción
Sumario:OBJECTIVE: Evaluate the efficacy of tranexamic acid in reducing bleeding in patients undergoing total knee arthroplasty. METHODS: 101 patients were randomized into two groups: the tranexamic acid group (n = 51) and the placebo group (n = 50). Patients were compared regarding the following parameters: reduction of hemoglobin, total estimated blood loss, drain output, and postoperative blood transfusion rate. RESULTS: Comparing the groups, there were statistically significant differences (p < 0.05) in the following parameters: reduction of hemoglobin, decreased hematocrit, estimated blood loss, and drain output. All values were lower in the tranexamic acid group. Only placebo group patients required blood transfusion. CONCLUSION: The use of intravenous tranexamic acid is effective to reduce bleeding in patients undergoing total knee arthroplasty.

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