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Expression, Clinical Significance, and Functional Prediction of MNX1 in Breast Cancer

Motor neuron and pancreas homeobox 1 (MNX1) is a key developmental gene. Previous studies found that it was upregulated in several tumors, but its role in breast cancer (BC) remains unclear. In order to have a better understanding of this gene in BC, we examined the expression of MNX1 in BC tissues...

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Autores principales: Tian, Tian, Wang, Meng, Zhu, Yuyao, Zhu, Wenge, Yang, Tielin, Li, Hongtao, Lin, Shuai, Dai, Cong, Deng, Yujiao, Song, Dingli, Li, Na, Zhai, Zhen, Dai, Zhi-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205149/
https://www.ncbi.nlm.nih.gov/pubmed/30368216
http://dx.doi.org/10.1016/j.omtn.2018.09.014
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author Tian, Tian
Wang, Meng
Zhu, Yuyao
Zhu, Wenge
Yang, Tielin
Li, Hongtao
Lin, Shuai
Dai, Cong
Deng, Yujiao
Song, Dingli
Li, Na
Zhai, Zhen
Dai, Zhi-Jun
author_facet Tian, Tian
Wang, Meng
Zhu, Yuyao
Zhu, Wenge
Yang, Tielin
Li, Hongtao
Lin, Shuai
Dai, Cong
Deng, Yujiao
Song, Dingli
Li, Na
Zhai, Zhen
Dai, Zhi-Jun
author_sort Tian, Tian
collection PubMed
description Motor neuron and pancreas homeobox 1 (MNX1) is a key developmental gene. Previous studies found that it was upregulated in several tumors, but its role in breast cancer (BC) remains unclear. In order to have a better understanding of this gene in BC, we examined the expression of MNX1 in BC tissues and normal breast tissues by qRT-PCR and by analyzing data from The Cancer Genome Atlas (TCGA) database. We also assessed the association of MNX1 expression with BC clinicopathological features and investigated the impact of MNX1 on BC survival. Potential molecular function of MNX1 was predicted through protein-protein interactions and functional enrichment. The results showed that the expression of MNX1 was significantly increased in BC tissues, especially in the HER2-positive subtype, and MNX1 expression was associated with several clinical characteristics, including menopause status, receptor status, subtypes, tumor size, lymph node metastasis, and race. In addition, patients with higher MNX1 expression had poorer survival. Enrichment analysis suggested that MNX1 is probably involved in biological processes and pathways related to nuclear division, cell cycle, and p53 signaling. In conclusion, our study suggests that MNX1 may act as a tumor promoter in BC. We hope these findings will draw more attention to MNX1 in future cancer studies.
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spelling pubmed-62051492018-11-05 Expression, Clinical Significance, and Functional Prediction of MNX1 in Breast Cancer Tian, Tian Wang, Meng Zhu, Yuyao Zhu, Wenge Yang, Tielin Li, Hongtao Lin, Shuai Dai, Cong Deng, Yujiao Song, Dingli Li, Na Zhai, Zhen Dai, Zhi-Jun Mol Ther Nucleic Acids Article Motor neuron and pancreas homeobox 1 (MNX1) is a key developmental gene. Previous studies found that it was upregulated in several tumors, but its role in breast cancer (BC) remains unclear. In order to have a better understanding of this gene in BC, we examined the expression of MNX1 in BC tissues and normal breast tissues by qRT-PCR and by analyzing data from The Cancer Genome Atlas (TCGA) database. We also assessed the association of MNX1 expression with BC clinicopathological features and investigated the impact of MNX1 on BC survival. Potential molecular function of MNX1 was predicted through protein-protein interactions and functional enrichment. The results showed that the expression of MNX1 was significantly increased in BC tissues, especially in the HER2-positive subtype, and MNX1 expression was associated with several clinical characteristics, including menopause status, receptor status, subtypes, tumor size, lymph node metastasis, and race. In addition, patients with higher MNX1 expression had poorer survival. Enrichment analysis suggested that MNX1 is probably involved in biological processes and pathways related to nuclear division, cell cycle, and p53 signaling. In conclusion, our study suggests that MNX1 may act as a tumor promoter in BC. We hope these findings will draw more attention to MNX1 in future cancer studies. American Society of Gene & Cell Therapy 2018-09-27 /pmc/articles/PMC6205149/ /pubmed/30368216 http://dx.doi.org/10.1016/j.omtn.2018.09.014 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tian, Tian
Wang, Meng
Zhu, Yuyao
Zhu, Wenge
Yang, Tielin
Li, Hongtao
Lin, Shuai
Dai, Cong
Deng, Yujiao
Song, Dingli
Li, Na
Zhai, Zhen
Dai, Zhi-Jun
Expression, Clinical Significance, and Functional Prediction of MNX1 in Breast Cancer
title Expression, Clinical Significance, and Functional Prediction of MNX1 in Breast Cancer
title_full Expression, Clinical Significance, and Functional Prediction of MNX1 in Breast Cancer
title_fullStr Expression, Clinical Significance, and Functional Prediction of MNX1 in Breast Cancer
title_full_unstemmed Expression, Clinical Significance, and Functional Prediction of MNX1 in Breast Cancer
title_short Expression, Clinical Significance, and Functional Prediction of MNX1 in Breast Cancer
title_sort expression, clinical significance, and functional prediction of mnx1 in breast cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205149/
https://www.ncbi.nlm.nih.gov/pubmed/30368216
http://dx.doi.org/10.1016/j.omtn.2018.09.014
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