Deletion of the glucocorticoid receptor chaperone FKBP51 prevents glucocorticoid-induced skin atrophy

FKBP51 (FK506-binding protein 51) is a known co-chaperone and regulator of the glucocorticoid receptor (GR), which usually attenuates its activity. FKBP51 is one of the major GR target genes in skin, but its role in clinical effects of glucocorticoids is not known. Here, we used FKBP51 knockout (KO)...

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Detalles Bibliográficos
Autores principales: Baida, Gleb, Bhalla, Pankaj, Yemelyanov, Alexander, Stechschulte, Lance A., Shou, Weinian, Readhead, Ben, Dudley, Joel T., Sánchez, Edwin R., Budunova, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205168/
https://www.ncbi.nlm.nih.gov/pubmed/30410676
http://dx.doi.org/10.18632/oncotarget.26194

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