PARP1 is required for preserving telomeric integrity but is dispensable for A-NHEJ

Poly-ADP ribose polymerase 1 (PARP1) is clinically important because of its synthetic lethality with breast cancer allele 1 and 2 mutations, which are causative for inherited breast and ovarian cancers. Biochemically, PARP1 is a single-stranded DNA break repair protein that is needed for preserving...

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Detalles Bibliográficos
Autores principales: Harvey, Adam, Mielke, Nicholas, Grimstead, Julia W., Jones, Rhiannon E., Nguyen, Thanh, Mueller, Matthew, Baird, Duncan M., Hendrickson, Eric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205175/
https://www.ncbi.nlm.nih.gov/pubmed/30410680
http://dx.doi.org/10.18632/oncotarget.26201

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